{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:55:25Z","timestamp":1789275325915,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81625020"],"award-info":[{"award-number":["No. 81625020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M662982"],"award-info":[{"award-number":["2019M662982"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A few single\u2010nucleotide polymorphisms (SNPs) have been identified to be associated with cutaneous melanoma (CM) survival through genome\u2010wide association studies, but stringent multiple testing corrections required for the hypothesis\u2010free testing may have masked some true associations. Using a hypothesis\u2010driven analysis approach, we sought to evaluate associations between SNPs in ketone body metabolic pathway genes and CM survival. We comprehensively assessed associations between 4196 (538 genotyped and 3658 imputed) common SNPs in 44 ketone body metabolic pathway genes and CM survival, using a dataset of 858 patients of a case\u2010control study from The University of Texas M.D. Anderson Cancer Center as the discovery set and another dataset of 409 patients from the Nurses' Health Study and the Health Professionals Follow\u2010up Study as the replication set. There were 95\/858 (11.1%) and 48\/409 (11.7%) patients who died of CM, respectively. We identified two independent SNPs (ie, <jats:italic>PDSS1<\/jats:italic> rs12254548 G&gt;C and <jats:italic>SLC16A6<\/jats:italic> rs71387392 G&gt;A) that were associated with CM survival, with allelic hazards ratios of 0.58 (95% confidence interval [CI]\u2009=\u20090.44\u20100.76, <jats:italic>P<\/jats:italic>\u2009=\u20099.00\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>) and 1.98 (95% CI\u2009=\u20091.34\u20102.94, <jats:italic>P<\/jats:italic>\u2009=\u20096.30\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>), respectively. Additionally, associations between genotypes of the SNPs and messenger RNA expression levels of their corresponding genes support the biologic plausibility of a role for these two variants in CM tumor progression and survival. Once validated by other larger studies, <jats:italic>PDSS1<\/jats:italic> rs12254548 and <jats:italic>SLC16A6<\/jats:italic> rs71387392 may be valuable biomarkers for CM survival.<\/jats:p>","DOI":"10.1002\/mc.23191","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T07:20:57Z","timestamp":1585639257000},"page":"640-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genetic variants in <i>PDSS1<\/i> and <i>SLC16A6<\/i> of the ketone body metabolic pathway predict cutaneous melanoma\u2010specific survival"],"prefix":"10.1002","volume":"59","author":[{"given":"Wei","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou Guangdong China"},{"name":"Duke Cancer Institute Duke University Medical Center  Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine  Durham North Carolina"},{"name":"Department of Dermatology Xijing Hospital, Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center  Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka","family":"Chen","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center  Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center  Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danwen","family":"Qian","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Medical Center  Durham North Carolina"},{"name":"Department of Medicine Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Amos","sequence":"additional","affiliation":[{"name":"Department of Medicine,\u00a0Baylor College of Medicine Institute for Clinical and Translational Research  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas M. 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