{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:11:16Z","timestamp":1782141076073,"version":"3.54.5"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epidemiological investigations implied that mitochondrial DNA copy number (mtDNAcn) variations could trigger predisposition to multiple cancers, but evidence regarding gastrointestinal cancers (GICs) was still uncertain. We conducted a case\u2010cohort study within the prospective Dongfeng\u2010Tongji cohort, including incident cases of colorectal cancer (CRC,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009278), gastric cancer (GC,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009138), and esophageal cancer (EC,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200972) as well as a random subcohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091173), who were followed up from baseline to the end of 2018. We determined baseline blood mtDNAcn and associations of mtDNAcn with the GICs risks were estimated by using weighted Cox proportional hazards models. Significant\n                    <jats:italic>U<\/jats:italic>\n                    \u2010shaped associations were observed between mtDNAcn and GICs risks. Compared to subjects within the second quartile (Q2) mtDNAcn subgroup, those within the 1st (Q1), 3rd (Q3), and 4th (Q4) quartile subgroups showed increased risks of CRC (hazard ratio [HR] [95% confidence interval, CI]\u2009=\u20092.27 [1.47\u20133.52], 1.65 [1.04\u20132.62], and 2.81 [1.85\u20134.28], respectively) and total GICs (HR [95%CI]\u2009=\u20091.84 [1.30\u20132.60], 1.47 [1.03\u20132.10], and 2.51 [1.82\u20133.47], respectively], and those within Q4 subgroup presented elevated GC and EC risks (HR [95% CI]\u2009=\u20092.16 [1.31\u20133.54] and 2.38 [1.13\u20135.02], respectively). Similar associations of mtDNAcn with CRC and total GICs risks remained in stratified analyzes by age, gender, smoking, and drinking status. This prospective case\u2010cohort study showed\n                    <jats:italic>U<\/jats:italic>\n                    \u2010shaped associations between mtDNAcn and GICs risks, but further research works are needed to uncover underlying biological mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/mc.23478","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T08:24:40Z","timestamp":1665995080000},"page":"224-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associations of mitochondrial DNA copy number with incident risks of gastrointestinal cancers: A prospective case\u2013cohort study"],"prefix":"10.1002","volume":"62","author":[{"given":"Xin","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansen","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guyanan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan 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College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handong","family":"Yang","sequence":"additional","affiliation":[{"name":"Dongfeng Central Hospital, Dongfeng Motor Corporation Hubei University of Medicine 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