{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:15:25Z","timestamp":1788142525658,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm defined by the presence of t(9;22)(q34;q11.2)\/<jats:italic>BCR::ABL1<\/jats:italic>. Additional chromosomal abnormalities play an important role in the progression to CML. However, the additional fusion gene was rarely reported such as <jats:italic>CBFB::MYH11<\/jats:italic>. In this report, we described two cases of the co\u2010occurrence of <jats:italic>BCR::ABL1<\/jats:italic> and <jats:italic>SET::NUP214<\/jats:italic> in CML\u2010BP for the first time, which is associated with poor outcomes during tyrosine kinase inhibitor\u00a0(TKI) treatment. Meanwhile, we retrospectively analyzed <jats:italic>SET::NUP214<\/jats:italic> fusion transcript of the two cases at initial diagnosis of the\u00a0CML chronic phase by quantitative RT\u2010PCR, and detected at a ratio of 1.63% and 1.50%, respectively. <jats:italic>SET::NUP214<\/jats:italic> may promote disease progression during the transformation of CML. This study highlights the importance of extended molecular testing at the initial diagnosis of CML\u2010CP\u00a0at TKI resistance and\/or disease transformation.<\/jats:p>","DOI":"10.1002\/mc.23480","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T08:35:06Z","timestamp":1667378106000},"page":"117-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Blast phase of chronic myeloid leukemia with concurrent <i>BCR::ABL1<\/i> and <i>SET::NUP214<\/i>: A report of two cases"],"prefix":"10.1002","volume":"62","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University Suzhou 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Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010ting","family":"Tao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jundan","family":"Xie","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Shen","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Thrombosis and Hemostasis, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic 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