{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:50:26Z","timestamp":1784735426519,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770164"],"award-info":[{"award-number":["81770164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Outcomes for patients with relapsed and refractory (R\/R) T\u2010cell acute lymphoblastic leukemia (T\u2010ALL) after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) are dismal, with few available treatments. Recently, identification of cancer patients harboring neurotrophic tropomyosin receptor kinase (NTRK) gene fusions is constantly increasing, especially with the advent of NTRK inhibitors. However, the role of ETV6\u2010NTRK3 in T\u2010ALL has not been investigated. This case represented the first detailed report of T\u2010ALL patient harboring a cryptic ETV6\u2010NTRK3 fusion with an unfavorable prognosis, not only because of leukemia resistant to the standard multiagent chemotherapy but also early relapse after allo\u2010HSCT. Acquired EP300 mutation was found at relapse, which could explain the cause of recurrence and affect the follow\u2010up treatment. Combined targeted therapy like larotrectinib allied with pan\u2010targeted BCL\u20102 inhibitor venetoclax, may be a potential maintenance treatment in R\/R ETV6\u2010NTRK3 positive leukemia after allo\u2010HSCT. The leukemic clonal evolution might be revealed through transcriptome sequencing and overcome by drugs with universal targets. Our case demonstrated that both comprehensive profiling techniques (such as transcriptome sequencing, multiparameter flow cytometry, and digital droplet polymerase chain reaction) and a multimodality treatment strategy were critical for anticipating an early relapse and personalized therapy of R\/R T\u2010cell leukemia.<\/jats:p>","DOI":"10.1002\/mc.23534","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T12:38:47Z","timestamp":1681130327000},"page":"899-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeted therapy using larotrectinib and venetoclax for the relapsed\/refractory T\u2010cell acute lymphoblastic leukemia harboring a cryptic ETV6\u2010NTRK3 fusion"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-5599","authenticated-orcid":false,"given":"Kuangguo","family":"Zhou","sequence":"first","affiliation":[{"name":"Department 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