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The intracellular transcription factor signal transducer and activator of transcription 3 (STAT3) is overexpressed and hyperactivated in most human cancers. In this study, the role of STAT3 in murine MPM was examined. Inhibition of the Janus kinase 2 (JAK2)\/STAT3 pathway with the selective inhibitor JSI\u2010124 has an antitumor effect in murine MPM. Specifically, we demonstrated that JSI\u2010124 inhibits murine MPM cell growth and induces apoptotic and autophagic cell death. Exposure of RN5 and AB12 cells to JSI\u2010124 resulted in apoptosis via the Bcl\u20102 family of proteins. JSI\u2010124 triggered autophagosome formation, accumulation, and conversion of LC3I to LC3II. Autophagy inhibitors, Chloroquine (CQ) and Bafilomycin A1 (Baf\u2010A1), inhibited autophagy and sensitized RN5 and AB12 cells to JSI\u2010124\u2010induced apoptosis. Our data indicate that JSI\u2010124 is a promising therapeutic agent for MPM treatment.<\/jats:p>","DOI":"10.1002\/mc.23623","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T11:50:13Z","timestamp":1693309813000},"page":"1888-1901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["JSI\u2010124 inhibits cell proliferation and tumor growth by inducing autophagy and apoptosis in murine malignant mesothelioma"],"prefix":"10.1002","volume":"62","author":[{"given":"Chengke","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, The Second Hospital, Cheeloo College of Medicine Shandong University Jinan Shandong People's Republic of China"},{"name":"Key Laboratory of Thoracic Cancer, Cheeloo College of Medicine Shandong University Jinan Shandong People's Republic of 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