{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:29:31Z","timestamp":1756992571620,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute promyelocytic leukemia (APL) with typically <jats:italic>PML::RARA<\/jats:italic> fusion gene caused by t (15;17) (q22; q12) was distinguished from other types of acute myeloid leukemia. In a subset of patients with APL, t (15;17) (q22;q21) and <jats:italic>PML::RARA<\/jats:italic> fusion cannot be detected. In this report, we identified the coexistence of <jats:italic>STAT3::RARA<\/jats:italic> and <jats:italic>RARA::STAT5b<\/jats:italic> fusions for the first time in a variant APL patient lacking t (15;17)(q22;q21)\/<jats:italic>PML::RARA<\/jats:italic> fusion. Then, this patient was resistant to all\u2010trans retinoic acid\u00a0combined arsenic trioxide chemotherapy. Accurate detection of RARA gene partners is crucial for variant APL, and effective therapeutic regime is urgently needed.<\/jats:p>","DOI":"10.1002\/mc.23672","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T13:09:48Z","timestamp":1703768988000},"page":"558-562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case"],"prefix":"10.1002","volume":"63","author":[{"given":"Tingting","family":"Tao","sequence":"first","affiliation":[{"name":"Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, Department of Haematology The First Affiliated Hospital of Soochow University Soochow University Suzhou Jiangsu People's Republic of China"},{"name":"Division of Haematolgy Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology Soochow University Suzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiannong","family":"Cen","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, Department of Haematology The First Affiliated Hospital of Soochow University Soochow University Suzhou Jiangsu People's Republic of China"},{"name":"Division of Haematolgy Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology Soochow University Suzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases, NHC Key Laboratory of Thrombosis and Hemostasis, Department of Haematology 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