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We enrolled 80 bladder cancer patients to examine the relationship between circTAF15 expression and clinical features. The function of circTAF15 on bladder cancer cell viability, proliferation, migration, invasion, and glycolysis was monitored by cell counting kit\u20108 assay, 5\u2010Ethynyl\u20102\u2032\u2010deoxyuridine experiment, Transwell experiment, and glycolysis analysis. Dual luciferase reporter gene assay, RNA pull\u2010down assay, and RNA immunoprecipitation assay were used to verify the binding between circTAF15 and miR\u2010502\u20105p or between miR\u2010502\u20105p and high mobility group box 3 (HMGB3). circTAF15 effect on in vivo growth of bladder cancer was investigated by xenograft tumor experiment. Quantitative real\u2010time polymerase chain reaction, Western blot, and immunohistochemistry were implemented to investigate the expression levels of genes. circTAF15 was upregulated in bladder cancer patients, associated with unfavorable outcomes. circTAF15 knockdown attenuated bladder cancer cell viability, proliferation, migration, invasion, epithelial\u2010mesenchymal transition, and glycolysis. circTAF15 suppressed miR\u2010502\u20105p expression, and miR\u2010502\u20105p inhibited HMGB3 expression. Low miR\u2010502\u20105p expression was associated with unfavorable outcomes in bladder cancer patients. miR\u2010502\u20105p silencing and HMGB3 overexpression counteracted the inhibition of circTAF15 knockdown on the malignant phenotype of bladder cancer cells. circTAF15 knockdown attenuated the in vivo growth of bladder cancer cells. circTAF15 enhanced the progression of bladder cancer through upregulating HMGB3 via suppressing miR\u2010502\u20105p. circTAF15 may be a novel target to treat bladder cancer in the future.<\/jats:p>","DOI":"10.1002\/mc.23677","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T14:19:43Z","timestamp":1705414783000},"page":"629-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["circRNA TATA\u2010box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR\u2010502\u20105p\/high mobility group box 3"],"prefix":"10.1002","volume":"63","author":[{"given":"Hong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Urology, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital The Third Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital The Third Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital The Third Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital The Third Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University Cancer Hospital Yunnan, Yunnan Cancer Hospital The Third Affiliated Hospital of Kunming Medical University Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"AbouelkheirRT AbdelhamidA Abou El\u2010GharM. 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