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Bioinformatics analysis revealed that AURKB was significantly overexpressed in HCC tissues and cell lines, and its high expression was associated with a poorer prognosis in HCC patients. Furthermore, downregulation of AURKB inhibited HCC cell proliferation, migration, and invasion, induced apoptosis, and caused cell cycle arrest. Moreover, AURKB downregulation also inhibited lung metastasis of HCC. AURKB interacted with\u00a0DExH\u2010Box helicase 9\u00a0(DHX9) and targeted its expression in HCC cells. Rescue experiments further demonstrated that AURKB targeting DHX9 promoted HCC progression through the PI3K\/AKT\/mTOR pathway. Our results suggest that AURKB is significantly highly expressed in HCC and correlates with patient prognosis. Targeting DHX9 with AURKB promotes HCC progression via the PI3K\/AKT\/mTOR pathway.<\/jats:p>","DOI":"10.1002\/mc.23775","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:40:32Z","timestamp":1718350832000},"page":"1814-1826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["AURKB targets DHX9 to promote hepatocellular carcinoma progression via PI3K\/AKT\/mTOR pathway"],"prefix":"10.1002","volume":"63","author":[{"given":"Guoqing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First Hospital of Nanchang The Third Affiliated Hospital of Nanchang University Nanchang Jiangxi Province China"},{"name":"Department of General Surgery The First Affiliated Hospital of Nanchang University Nanchang Jiangxi Province 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