{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:35:53Z","timestamp":1787801753321,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01676"],"award-info":[{"award-number":["2023J01676"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>LAIR1, a receptor found on immune cells, is capable of binding to collagen and is involved in immune\u2010related diseases. However, the precise contribution of LAIR1 expressed on hepatocellular carcinoma (HCC)\u00a0cells to tumor microenvironment is still unclear. In our study, bioinformatics analysis and immunofluorescence were employed to study the correlation between LAIR1 levels and clinical indicators. Transwell and scratch tests were used to evaluate how LAIR1 affected the migration and invasion of HCC cells. The chemotactic capacity and alternative activation of macrophages were investigated using RT\u2010qPCR,\u00a0transwell, and immunofluorescence. To investigate the molecular mechanisms, transcriptome sequencing analysis, Western blot, nucleus\/cytoplasm fractionation, ELISA, and cytokine microarray were employed. We revealed a significant correlation between the presence of LAIR1 and an unfavorable outcome in HCC. We indicated that LAIR1 promoted migration and invasion of HCC cells through the AKT\u2010IKK\u03b2\u2010p65\u00a0axis. Additionally, the alternative activation and infiltration of tumor\u2010associated macrophages induced by LAIR1 were reliant on the upregulation of IL6 and CCL5 within this axis, respectively. In conclusion, blocking LAIR1 was found to be an effective approach in combating the cancerous advancement of HCC.<\/jats:p>","DOI":"10.1002\/mc.23776","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T13:10:45Z","timestamp":1721221845000},"page":"1827-1841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["LAIR1 promotes hepatocellular carcinoma cell metastasis and induces M2\u2010macrophage infiltration through activating AKT\u2010IKK\u03b2\u2010p65 axis"],"prefix":"10.1002","volume":"63","author":[{"given":"Banglun","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"},{"name":"Cancer Center of Fujian Medical University, Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-5254","authenticated-orcid":false,"given":"Nanhong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery Fujian Medical University Union Hospital Fuzhou China"},{"name":"Cancer Center of Fujian Medical University, Fujian Medical University Union Hospital Fuzhou China"},{"name":"Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University) Fujian Province University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1713263"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2023.07.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.02.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-017-3498-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-023-00830-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907609"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.996026"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111039"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2018.04.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012541"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i2.165"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00038"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04716-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0307"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12172143"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00445"},{"key":"e_1_2_10_19_1","first-page":"32","article-title":"Systematic prediction of orthologous units of genes in the complete genomes","volume":"9","author":"Bono H","year":"1998","journal-title":"Genome Inform Ser Workshop Genome Inform"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205117"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14141"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01930"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00689-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12345"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00484-9"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111605"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103589"},{"issue":"2","key":"e_1_2_10_29_1","first-page":"1293","article-title":"Leukocyte\u2011associated immunoglobulin\u2011like receptor 1 promotes tumorigenesis in RCC","volume":"41","author":"Jingushi K","year":"2019","journal-title":"Oncol Rep"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010080"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62927"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.012"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114113"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24734"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.10.006"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.23776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T17:31:23Z","timestamp":1723829483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.23776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/mc.23776"],"URL":"https:\/\/doi.org\/10.1002\/mc.23776","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"2024-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}