{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T14:55:08Z","timestamp":1766588108472,"version":"3.37.3"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The tumorigenesis of intrahepatic cholangiocarcinoma (ICC) has been identified to be exceptionally involved in dysregulated Hippo\/Yes\u2010associated protein (YAP) signaling pathway (Hippo\/YAP). Hippo\/YAP functions as a master regulator engaged in a plethora of physiological and oncogenic processes as well. Therefore, the aberrant Hippo\/YAP could serve as an Achilles' heel regarding the molecular therapeutic avenues for ICC patients. Herein, we comprehensively review the recent studies about the underlying mechanism of disrupted Hippo\/YAP in ICC, how diagnostic values could be utilized upon the critical genes in this pathway, and what opportunities could be given upon this target pathway.<\/jats:p>","DOI":"10.1002\/mc.23791","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T11:28:32Z","timestamp":1722598112000},"page":"1866-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting Hippo\/YAP in intrahepatic cholangiocarcinoma: Promising molecules in cancer therapy"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6319-7277","authenticated-orcid":false,"given":"Xing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianmin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1016\/S0140-6736(13)61903-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1053\/j.gastro.2013.10.013"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1038\/nrclinonc.2017.157"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.21037\/cco.2018.07.03"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1038\/s41572-021-00300-2"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1111\/liv.14093"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1001\/jamasurg.2013.5137"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1007\/s11605-007-0335-4"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1016\/j.gtc.2018.01.002"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1002\/lt.20512"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1016\/j.jhep.2019.10.009"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1002\/hep.30289"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1016\/j.cell.2014.03.060"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1016\/j.jhep.2021.08.027"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1016\/j.canlet.2016.08.013"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1186\/s12935-022-02840-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1016\/j.devcel.2010.09.011"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1073\/pnas.0912203107"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1021\/acs.biochem.6b00763"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1016\/j.taap.2020.115257"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1038\/s41418-020-0544-x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1053\/j.gastro.2013.02.037"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1038\/5965"},{"key":"e_1_2_8_25_1","first-page":"491","article-title":"WWC1 and NF2 prevent the development of intrahepatic cholangiocarcinoma by regulating YAP\/TAZ activity through LATS in mice","volume":"43","author":"Park J","year":"2020","journal-title":"Mol Cells"},{"doi-asserted-by":"publisher","key":"e_1_2_8_26_1","DOI":"10.3390\/cancers12092438"},{"key":"e_1_2_8_27_1","first-page":"2145","article-title":"Yes\u2010associated protein (YAP65) is a proline\u2010rich phosphoprotein that binds to the SH3 domain of the Yes proto\u2010oncogene product","volume":"9","author":"Sudol M","year":"1994","journal-title":"Oncogene"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.3892\/ijo.2015.2877"},{"doi-asserted-by":"publisher","key":"e_1_2_8_29_1","DOI":"10.1016\/j.molmed.2006.11.006"},{"doi-asserted-by":"publisher","key":"e_1_2_8_30_1","DOI":"10.1016\/j.canlet.2022.215917"},{"doi-asserted-by":"publisher","key":"e_1_2_8_31_1","DOI":"10.1038\/s41419-023-05657-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_32_1","DOI":"10.1038\/s41419-022-05474-5"},{"doi-asserted-by":"crossref","unstructured":"LiuZ HayashiH MatsumuraK et al:Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial\u2010mesenchymal transitions via YAP\/TAZ\u2010Hedgehog signalling axis in pancreatic cancer.Br J Cancer2022.","key":"e_1_2_8_33_1","DOI":"10.1038\/s41416-022-02106-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_34_1","DOI":"10.1186\/s41232-022-00235-5"},{"doi-asserted-by":"publisher","key":"e_1_2_8_35_1","DOI":"10.1016\/j.ccr.2009.09.026"},{"doi-asserted-by":"publisher","key":"e_1_2_8_36_1","DOI":"10.21037\/jtd.2017.03.179"},{"key":"e_1_2_8_37_1","first-page":"2993","article-title":"Yes\u2010associated protein (YAP) predicts poor prognosis and regulates progression of esophageal squamous cell cancer through epithelial\u2010mesenchymal transition","volume":"18","author":"Qu Y","year":"2019","journal-title":"Exp Ther Med"},{"doi-asserted-by":"publisher","key":"e_1_2_8_38_1","DOI":"10.1080\/19336950.2022.2099381"},{"doi-asserted-by":"publisher","key":"e_1_2_8_39_1","DOI":"10.1016\/j.jhep.2021.05.041"},{"doi-asserted-by":"publisher","key":"e_1_2_8_40_1","DOI":"10.1016\/j.jhep.2018.05.008"},{"doi-asserted-by":"publisher","key":"e_1_2_8_41_1","DOI":"10.3390\/ijms20030581"},{"doi-asserted-by":"publisher","key":"e_1_2_8_42_1","DOI":"10.1038\/nature11693"},{"doi-asserted-by":"publisher","key":"e_1_2_8_43_1","DOI":"10.1016\/j.yexcr.2013.01.020"},{"doi-asserted-by":"publisher","key":"e_1_2_8_44_1","DOI":"10.1016\/j.cellsig.2014.09.011"},{"doi-asserted-by":"publisher","key":"e_1_2_8_45_1","DOI":"10.1007\/s00535-019-01563-z"},{"doi-asserted-by":"publisher","key":"e_1_2_8_46_1","DOI":"10.1016\/j.ajpath.2019.05.014"},{"doi-asserted-by":"publisher","key":"e_1_2_8_47_1","DOI":"10.1021\/acs.biochem.5b01014"},{"doi-asserted-by":"publisher","key":"e_1_2_8_48_1","DOI":"10.1016\/bs.acr.2022.02.003"},{"doi-asserted-by":"publisher","key":"e_1_2_8_49_1","DOI":"10.1016\/j.cell.2007.12.018"},{"doi-asserted-by":"publisher","key":"e_1_2_8_50_1","DOI":"10.1073\/pnas.0911409107"},{"doi-asserted-by":"publisher","key":"e_1_2_8_51_1","DOI":"10.1073\/pnas.1517188113"},{"doi-asserted-by":"publisher","key":"e_1_2_8_52_1","DOI":"10.1002\/hep.29647"},{"doi-asserted-by":"publisher","key":"e_1_2_8_53_1","DOI":"10.1101\/gad.350127.122"},{"doi-asserted-by":"publisher","key":"e_1_2_8_54_1","DOI":"10.1053\/j.gastro.2022.05.007"},{"doi-asserted-by":"publisher","key":"e_1_2_8_55_1","DOI":"10.1038\/s41467-018-05939-2"},{"doi-asserted-by":"publisher","key":"e_1_2_8_56_1","DOI":"10.1016\/j.celrep.2021.109310"},{"doi-asserted-by":"publisher","key":"e_1_2_8_57_1","DOI":"10.1038\/s41419-021-04305-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_58_1","DOI":"10.1016\/j.jhep.2021.11.010"},{"doi-asserted-by":"crossref","unstructured":"ChenY YangS LiuL et al.:Knockdown of FGFR3 inhibits the proliferation migration and invasion of intrahepatic cholangiocarcinoma.Digest Liver Dis.2022.","key":"e_1_2_8_59_1","DOI":"10.1016\/j.dld.2022.07.017"},{"doi-asserted-by":"publisher","key":"e_1_2_8_60_1","DOI":"10.1371\/journal.pgen.1004135"},{"doi-asserted-by":"publisher","key":"e_1_2_8_61_1","DOI":"10.1016\/j.humpath.2014.03.014"},{"doi-asserted-by":"publisher","key":"e_1_2_8_62_1","DOI":"10.1038\/s41698-022-00320-5"},{"doi-asserted-by":"publisher","key":"e_1_2_8_63_1","DOI":"10.1002\/hep.32483"},{"doi-asserted-by":"publisher","key":"e_1_2_8_64_1","DOI":"10.1016\/j.celrep.2022.111296"},{"doi-asserted-by":"publisher","key":"e_1_2_8_65_1","DOI":"10.3390\/biomedicines9121949"},{"doi-asserted-by":"publisher","key":"e_1_2_8_66_1","DOI":"10.3390\/cancers13030558"},{"doi-asserted-by":"publisher","key":"e_1_2_8_67_1","DOI":"10.1126\/science.aan6733"},{"doi-asserted-by":"publisher","key":"e_1_2_8_68_1","DOI":"10.1001\/jamaoncol.2020.0930"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.23791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T15:07:36Z","timestamp":1727190456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.23791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,2]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/mc.23791"],"URL":"https:\/\/doi.org\/10.1002\/mc.23791","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"type":"print","value":"0899-1987"},{"type":"electronic","value":"1098-2744"}],"subject":[],"published":{"date-parts":[[2024,8,2]]},"assertion":[{"value":"2023-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}