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In this study, we found that the anchoring filament protein ladinin 1 (LAD1) specifically binds to LINC01305 for co\u2010regulating the level of modulating cortactin proteins (CTTN) and neuronal Wiskott\u2013Aldrich syndrome protein (N\u2010WASP) phosphorylation, which mediates cytoskeletal reorganization and affects the metastasis of ESCC cells. Additionally, LINC01305 and LAD1 jointly promoted the epithelial\u2013mesenchymal transition (EMT) process by activating the phosphoinositide\u20103\u2010kinase\u2013protein kinase B (PI3K\/AKT) signaling pathway. Moreover, LINC01305 and LAD1 were related to the late clinical stage and lymph node metastasis of ESCC. Our study demonstrated that LINC01305 and LAD1 are major determinants of ESCC dissemination and revealed a novel molecular mechanism of cytoskeletal reorganization that controls ESCC metastasis.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> N\/A.<\/jats:p>","DOI":"10.1002\/mc.23885","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:47:05Z","timestamp":1737460025000},"page":"756-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["LINC01305 and LAD1 Co\u2010Regulate CTTN and N\u2010WASP Phosphorylation, Mediating Cytoskeletal Reorganization to Promote ESCC Metastasis"],"prefix":"10.1002","volume":"64","author":[{"given":"Hang","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Tissue Engineering and Stem Cells, Beijing Anzhen Nanchong Hospital of Capital Medical University, Nanchong Central Hospital, The Second Clinical Medical College of 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