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This study investigates the role of MEMRGs in intrahepatic cholangiocarcinoma (ICC) by analyzing RNA\u2010seq data from TCGA and GEO databases to identify differentially expressed MEMRGs. Functional enrichment and KEGG pathway analyses revealed their significant involvement in metabolic pathways. Using weighted gene co\u2010expression network analysis (WGCNA) and consensus clustering, two distinct ICC subtypes were identified. Tumor mutational burden (TMB), immune cell infiltration, and immune escape potential were assessed, highlighting the importance of the Hippo\/YAP pathway. Cox regression analyses pinpointed key prognostic genes, including <jats:italic>ADH1A<\/jats:italic>, <jats:italic>ADH1B<\/jats:italic>, and <jats:italic>CYP4A11<\/jats:italic>. A MEMRG\u2010based nomogram was developed that accurately predicted 1\u2010 and 3\u2010year survival outcomes. Experimental validation showed that <jats:italic>ADH1B<\/jats:italic> suppresses ICC malignancy through the Hippo\/YAP pathway. 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