{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:44:57Z","timestamp":1762271097714},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":6409,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human hereditary diseases such as xeroderma pigmentosum, Fanconi's anemia, ataxia telangiectasia, and Bloom's syndrome are characterized by a proneness for developing cancer associated with abnormalities in the processing of DNA damage. The molecular defects responsible for predisposing human tissues to cancer are still not well understood, despite the fact that a considerable amount of work has already been done on this problem. In this paper, we show that in human tumor cell lines, in cells transformed by DNA tumor viruses, and in cells derived from certain cancer\u2010prone disorders, the level of activity of a 42\u2010kDa deoxyribonuclease is many times higher than in diploid untransformed control cells. This suggests that this activity is linked to, or may play a role in, malignant transformation.<\/jats:p>","DOI":"10.1002\/mc.2940020402","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T19:29:08Z","timestamp":1172086148000},"page":"179-183","source":"Crossref","is-referenced-by-count":6,"title":["Enhanced Deoxyribonuclease Activity in Human Transformed Cells and in Bloom's Syndrome Cells"],"prefix":"10.1002","volume":"2","author":[{"given":"Mauro","family":"Mezzina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvano","family":"Nocentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Nardelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Renault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel","family":"Moustacchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Sarasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"343","volume-title":"DNA Repair","author":"Friedberg EC","year":"1984"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/325355a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/325357a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.22.8016"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"18231","DOI":"10.1016\/S0021-9258(19)81350-9","article-title":"Defective DNA ligase I in Bloom's syndrome cells","volume":"263","author":"Chan JYH","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.8.3091"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.12.5109"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(77)90627-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(83)91024-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"8074","DOI":"10.1016\/S0021-9258(18)43390-X","article-title":"Purification and characterization of DNase VII, a 3\u2032\u20105\u2032\u2010Directed exonuclease from human placenta","volume":"256","author":"Hollis GF","year":"1981","journal-title":"J Biol Chem"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/298393a0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.62.2.597"},{"key":"e_1_2_1_14_2","first-page":"3","volume-title":"Molecular and Cellular Repair Processes","author":"Lindahl T","year":"1972"},{"key":"e_1_2_1_15_2","first-page":"791","article-title":"Preneoplastic phenotype and chromosome changes of cultured human Bloom syndrome fibroblasts (strain GM1492)","volume":"46","author":"Brothman AR","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90063-X"},{"key":"e_1_2_1_17_2","volume-title":"DNA Replication","author":"Kornberg A","year":"1980"},{"key":"e_1_2_1_18_2","first-page":"1229","article-title":"Establishment and characterization of a melanoma cell line from a xeroderma pigmentosum patient: Activation of N\u2010ras at a potential pyrimidine dimer site","volume":"49","author":"Keijzer W","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/5.11.4317"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmc.2940020402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.2940020402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T16:48:37Z","timestamp":1697906917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.2940020402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1002\/mc.2940020402"],"URL":"https:\/\/doi.org\/10.1002\/mc.2940020402","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}