{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:23:48Z","timestamp":1762100628022},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5314,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The expression of the transin, c\u2010<jats:italic>fos<\/jats:italic>, and c\u2010<jats:italic>jun<\/jats:italic> genes was assessed in transplantable osteosarcomas and malignant fibrous histiocytomas, as well as in pancreatic duct adenocarcinomas and hepatocellular carcinomas of rats and hamsters. Northern blot analysis revealed that both an undifferentiated osteosarcoma of spontaneous origin (SOS) and 4\u2010hydroxyaminoquinoline 1\u2010oxide (4\u2010HAQO)\u2010induced malignant fibrous histiocytomas with metastatic potential to the lung showed remarkably increased expression of transin mRNA transcripts. This was not the case for the other tumors. Interestingly, levels of transin mRNA were lower in lung metastatic lesions than in primary subcutaneous SOS tumors. The primary SOS and MFH expressed both c\u2010<jats:italic>fos<\/jats:italic> and c\u2010<jats:italic>jun<\/jats:italic> genes in conjunction with the transin gene, whereas the non\u2010transin expressers, a 4\u2010HAQO\u2010induced osteosarcoma (COS) and the pancreatic duct adenocarcinomas, demonstrated one or the other, but not both. These results suggest a possible involvement of transin expression in the progression of spontaneous osteosarcomas and 4\u2010HAQO\u2010induced malignant fibrous histiocytomas in rats. Expression of the c\u2010<jats:italic>fos<\/jats:italic> and c\u2010<jats:italic>jun<\/jats:italic> genes may play a regulatory role in this process. \u00a9 1992 wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mc.2940060207","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T20:04:01Z","timestamp":1172088241000},"page":"122-128","source":"Crossref","is-referenced-by-count":12,"title":["Expression of the transin, c\u2010<i>fos<\/i>, and c\u2010<i>jun<\/i> genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas"],"prefix":"10.1002","volume":"6","author":[{"given":"Kanya","family":"Honoki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Tsujiuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kondoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Shiraiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshizumi","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Mii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Tim Bowden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-7511-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(82)90020-8"},{"key":"e_1_2_1_4_2","first-page":"3","volume-title":"Current Problems in Cancer","author":"Nicolson GL","year":"1982"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03799.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9413"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.2940010106"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90024-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.5.1679"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90195-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2462278"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.8.4284"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1988.tb00027.x"},{"key":"e_1_2_1_14_2","first-page":"2057","article-title":"Experimental studies on malignant fibrous histiocytomas in rats: I","volume":"50","author":"Mii Y","year":"1982","journal-title":"Production of malignant fibrous histiocytomas by 4\u2010hydroxyaminoquinoline 1\u2010oxide in bone of Fischer 344 strain rats. 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