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Herein, we synthesize decades of research regarding HIF and autophagy in cancer, highlighting their regulatory roles in modulating progression, such as HIF\u20101\u03b1\u2013BNIP3\/BNIP3L\u2013Beclin\u20101 complex signaling and HIF\u2013mTOR\u2013ULK1 axis. Given the paucity of comprehensive syntheses regarding this intricate interplay, we systematically deconstruct recent findings to map the molecular landscape connecting HIF\u20101 to autophagic flux and cell death. Specifically, we explore the metabolic bridges linking HIF and autophagy, including glycolysis and reactive oxygen species (ROS). Furthermore, by refining the content of dual\u2010target molecules, we propose strategies for co\u2010targeting HIF and autophagy, aiming to catalyze the development of novel therapeutic interventions.<\/jats:p>","DOI":"10.1002\/mc.70081","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T10:28:18Z","timestamp":1767781698000},"page":"291-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insights Into the Crosstalk of HIF and Autophagy: Regulation Mechanisms and Therapeutic Potentials in Cancer"],"prefix":"10.1002","volume":"65","author":[{"given":"Chaolei","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medical Technology Tianjin University of Traditional Chinese Medicine Tianjin People's Republic of China"},{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine Tianjin People's Republic of 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