{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:53:54Z","timestamp":1773212034714,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373064"],"award-info":[{"award-number":["82373064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972480"],"award-info":[{"award-number":["81972480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chemotherapy resistance is the primary cause of clinical treatment failure and unfavorable prognosis among breast cancer patients. Consequently, the exploration of novel molecular targets for chemotherapy resistance is warranted. Here, we demonstrated that Zinc Finger Protein 184 (ZNF184) facilitates chemoresistance in breast cancer. Through integrated bioinformatics and experimental validation, we identified that ZNF184 was highly expressed in paclitaxel\u2010resistant breast cancer cells. Knockdown of ZNF184 inhibited cell proliferation and re\u2010sensitized resistant cells to paclitaxel in vitro and in patients\u2010derived organoids (PDOs). Mechanistically, ZNF184 regulates the expression of stemness\u2010related genes CD44, OCT4, Nanog, SOX2, and ALDH1A1, thereby promoting the proliferation of breast cancer cells and subsequent paclitaxel resistance. Pan\u2010cancer analysis revealed the potential of ZNF184 as a prognostic and predictive biomarker for adverse clinical outcomes. Collectively, these findings reveal a previously unknown role of ZNF184 in breast cancer progression and paclitaxel resistance, providing new insights into ZNF184 as a potential therapeutic target for cancer patients.<\/jats:p>","DOI":"10.1002\/mc.70088","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T18:10:21Z","timestamp":1770315021000},"page":"493-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Analysis Reveals ZNF184 as a Novel Regulator of Stemness\u2010Associated Paclitaxel Resistance and Tumor Progression in Breast Cancer"],"prefix":"10.1002","volume":"65","author":[{"given":"Rong","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital Central South University Changsha China"},{"name":"Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital Central South University Changsha China"},{"name":"Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital Central South University Changsha China"},{"name":"Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital Central South University Changsha China"},{"name":"Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital Central South University Changsha China"},{"name":"Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anze","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhuzhou Nanfang High School Zhuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidi","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruigang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Information and Network Center Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-0443","authenticated-orcid":false,"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Xiangya Hospital Central South University Changsha China"},{"name":"Hunan Provincial Engineering Research Center of Translational Medicine and Innovative Drug Changsha China"},{"name":"FuRong Laboratory Changsha China"},{"name":"NHC Key Laboratory of Cancer Proteomics &amp; State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital Central South University Changsha China"},{"name":"Clinical Research Center for Breast Disease in Hunan Province Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20211033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19323"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e14-04-0916"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107534"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2020.100742"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101223"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.01.026"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01127-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa407"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx247"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2022.01.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan2507"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"issue":"3","key":"e_1_2_9_16_1","article-title":"Integrated Analysis of Public Datasets for the Discovery and Validation of Survival\u2010Associated Genes in Solid Tumors","volume":"5","author":"Gy\u0151rffy B.","year":"2024","journal-title":"Innovation"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz430"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181ec173d"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1090"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz401"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky939"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00430-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01863-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0056-x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4409"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.09.024"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.70088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mc.70088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.70088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:09:07Z","timestamp":1773133747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.70088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/mc.70088"],"URL":"https:\/\/doi.org\/10.1002\/mc.70088","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"2025-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}