{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:21:24Z","timestamp":1788510084089,"version":"build-2803163510"},"reference-count":76,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Gastric cancer (GC) is the fifth most common type worldwide, representing a public health problem. Among the genes related to this tumorigenesis, the family of matrix metalloproteinases (MMPs), essential regulators of the extracellular matrix (ECM), stand out for their involvement in the development and progression of GC. Therefore, we aimed to evaluate\n                    <jats:italic>MMP<\/jats:italic>\n                    gene expression variation, its relationship with clinicopathological factors and its transcriptome\u2010wide associations. To this end, RNAseq, correlation network, and biological pathway enrichment analyses were performed on tumor samples from GC and peritumoral samples from patients treated at a reference center in the Northern region of Brazil. Among the 22 investigated\n                    <jats:italic>MMPs<\/jats:italic>\n                    , seven genes (\n                    <jats:italic>MMP2, MMP3, MMP10, MMP12, MMP14, MMP15<\/jats:italic>\n                    , and\n                    <jats:italic>MMP16<\/jats:italic>\n                    ) were upregulated in cancer, while\n                    <jats:italic>MMP8<\/jats:italic>\n                    was downregulated. Increased expression of seven of the eight differentially expressed\n                    <jats:italic>MMPs<\/jats:italic>\n                    was found in early stages of the disease compared to Tumor, Node, Metastasis (TNM) stage IV.\n                    <jats:italic>MMP16<\/jats:italic>\n                    showed higher expression in the diffuse\u2010type gastric adenocarcinoma. An increased expression of\n                    <jats:italic>MMP10<\/jats:italic>\n                    was observed in the EBV\/TCGA group. A significant reduction in survival was noticed in those patients with lower expression of\n                    <jats:italic>MMP8, MMP12<\/jats:italic>\n                    , and\n                    <jats:italic>MMP14<\/jats:italic>\n                    . Transcriptomic correlation analyses demonstrated that differentially expressed\n                    <jats:italic>MMPs<\/jats:italic>\n                    interact with genes likely involved in cell adhesion, ECM organization, and immune response, such as\n                    <jats:italic>COL1A2, CDH11, KIRREL1, PPP1R14D, CEACAM8, ZNF423<\/jats:italic>\n                    , and\n                    <jats:italic>PRRX1<\/jats:italic>\n                    . The enrichment of biological pathways suggests involvement in processes such as ECM organization, collagen and proteoglycan degradation, suggesting that these genes possibly are involved in carcinogenic dynamics, supporting the role of\n                    <jats:italic>MMPs<\/jats:italic>\n                    in tumor ECM reorganization.\n                  <\/jats:p>","DOI":"10.1002\/mc.70097","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:54:29Z","timestamp":1773032069000},"page":"577-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of the Matrix Metalloproteinases Family Profile in Gastric Cancer Suggests Key Matrix Metalloproteinases for Tumor Development and Their Clinical Impact"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-9693","authenticated-orcid":false,"given":"Aline Costa","family":"Bastos","sequence":"first","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3451-6369","authenticated-orcid":false,"given":"Andr\u00e9 Salim","family":"Khayat","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"},{"name":"Institute of Biological Sciences Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele Raimunda Louzada","family":"Moraes","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-3786","authenticated-orcid":false,"given":"\u00c1gatha Tereza Miranda","family":"Tavares","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Matheus da Silva","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano Cordeiro","family":"Moreira","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-3381","authenticated-orcid":false,"given":"Samir Mansour Moraes","family":"Casseb","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Demachki","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo","family":"Ishak","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Williams Fernandes","family":"Barra","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rommel Mario Rodr\u00edguez","family":"Burbano","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"},{"name":"Molecular Biology Laboratory Hospital Ophir Loyola Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Pimentel","family":"de Assump\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Oncology Research Center Federal University of Par\u00e1 Belem Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16172948"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24827"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21114012"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000701"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.03.026"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033820935477"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07920.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.06.004"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"146","article-title":"Matrix 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