{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:37Z","timestamp":1786978177396,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    SLC25A22 is a mitochondrial inner membrane glutamate transporter responsible for shuttling glutamate from the cytoplasm into the mitochondrial matrix. Its clinical significance in gastric cancer (GC) remains unclear. GC can be classified into four molecular subtypes: Epstein\u2010Barr virus (EBV)\u2010associated, microsatellite instability (MSI), genomic stability (GS), and chromosomal instability (CIN). In this study, we evaluated the distribution of GC molecular subtypes in Taiwan and examined the association between SLC25A22 expression and patient outcomes. A total of 235 patients with gastric adenocarcinoma treated at Changhua Christian Hospital were included. Tumor subtypes were determined using immunohistochemistry and Epstein\u2010Barr encoding region (EBER) in situ hybridization according to established criteria, and SLC25A22 expression was assessed using an immunohistochemical scoring system. The prevalence of EBV\u2010associated tumors, MMR deficiency (MSI subtype), CIN, and other subtypes was 8.1%, 6.8%, 70.2%, and 14.9%, respectively. EBV\u2010associated tumors showed a relatively lower incidence of metastatic disease (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014). The median SLC25A22 expression scores were 85 in EBV\u2010associated tumors, 90 in MMR\u2010deficient tumors, 90 in CIN tumors, and 100 in other subtypes. Higher SLC25A22 expression (score\u2009&gt;\u200990) was associated with poorer prognosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014). Our findings indicate that the MSI subtype of GC has a relatively low prevalence in Taiwan and suggest that elevated SLC25A22 expression may serve as a potential biomarker associated with unfavorable prognosis in gastric cancer. Further studies are needed to clarify the biological role of SLC25A22 in tumor progression and therapeutic resistance.\n                  <\/jats:p>","DOI":"10.1002\/mc.70111","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:20:53Z","timestamp":1774293653000},"page":"770-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Molecular Subtypes of Gastric Cancer in Taiwan and the Impact of High SLC25A22 Expression on Survival: A Single\u2010Center Experience"],"prefix":"10.1002","volume":"65","author":[{"given":"Yu\u2010Ting","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital Division of Hematology and Oncology Chiayi Taiwan"},{"name":"Department of Biomedical Sciences National Chung Cheng University, Min\u2010Hsiung Chiayi Taiwan"},{"name":"Epigenomics and Human Disease Research Center National Chung Cheng University, Min\u2010Hsiung Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Hui","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Changhua Christian Hospital Changhua Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine College of Medicine, National Chung Hsing University Taichung Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology Central Taiwan University of Science and Technology Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun\u2010Tu","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Changhua Christian Hospital Changhua Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit\u2010San","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital Division of Hematology and Oncology Chiayi Taiwan"},{"name":"Department of Biomedical Sciences National Chung Cheng University, Min\u2010Hsiung Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Yen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences National Chung Cheng University, Min\u2010Hsiung Chiayi Taiwan"},{"name":"Epigenomics and Human Disease Research Center National Chung Cheng University, Min\u2010Hsiung Chiayi Taiwan"},{"name":"INSERM, UMR 1260, Regenerative Nanomedicine, University of Strasbourg, FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de L'Universit\u00e9 de Strasbourg) Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W. Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences National Chung Cheng University, Min\u2010Hsiung Chiayi Taiwan"},{"name":"Epigenomics and Human Disease Research Center National Chung Cheng University, Min\u2010Hsiung Chiayi Taiwan"},{"name":"Research Center for Precision Environmental Medicine, Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30354-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15839-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12914"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0355"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2240-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.71"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.08.016"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15383"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2024.5677"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-37870-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.3_suppl.387"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cson.2023.100031"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.3_suppl.389"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.14081"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.05.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2211"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0746-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2022.0203"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127511"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.70111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mc.70111","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.70111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:18:17Z","timestamp":1778851097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.70111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/mc.70111"],"URL":"https:\/\/doi.org\/10.1002\/mc.70111","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"2025-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}