{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T22:04:50Z","timestamp":1784153090385,"version":"3.55.0"},"reference-count":79,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    B cells are integral components of the tumor microenvironment (TME) and influence the progression, prognosis, and immunotherapy response of gastric cancer (GC). However, the prognostic relevance of germline variants in B cell\u2010related immune genes remains undefined. We performed a two\u2010stage genome\u2010wide association analysis to identify single\u2010nucleotide polymorphisms (SNPs) in B cell\u2010related immune genes associated with overall survival (OS) in patients with pathologic tumor\u2010node\u2010metastasis (pTNM) stage I\u2013III GC. Clinical, follow\u2010up, and genome\u2010wide association study (GWAS) genotyping data were analyzed from two independent Eastern Chinese cohorts (Shanghai,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20092211; Jiangsu,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20091049). Functional annotation, quantitative trait loci (QTL), and immune infiltration analyses were conducted. Among 15,857 SNPs across 223 genes, 210 were associated with OS in the discovery cohort, nine of which were validated. Two independent functional variants\u2014\n                    <jats:italic>FCER1A<\/jats:italic>\n                    rs539959920 C\u2009&gt;\u2009T and\n                    <jats:italic>PLCG2<\/jats:italic>\n                    rs72832034 C\u2009&gt;\u2009T\u2014were consistently associated with poorer OS (adjusted HR\u2009=\u20091.19, 95% CI\u2009=\u20091.04\u20131.37,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014; HR\u2009=\u20091.34, 95% CI\u2009=\u20091.09\u20131.64,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005). Patients carrying multiple unfavorable genotypes exhibited a dose\u2010dependent decline in survival (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>trend<\/jats:sub>\n                    \u2009=\u20090.002). Incorporation of these SNPs modestly improved time\u2010dependent AUCs for OS prediction at 36 months. Single\u2010cell expression and splicing QTL analyses demonstrated allele\u2010specific modulation of\n                    <jats:italic>FCER1A<\/jats:italic>\n                    and\n                    <jats:italic>PLCG2<\/jats:italic>\n                    expression across immune cell subsets, consistent with altered immune infiltration patterns in the GC TME. These findings suggest that two germline variants in\n                    <jats:italic>FCER1A<\/jats:italic>\n                    and\n                    <jats:italic>PLCG2<\/jats:italic>\n                    independently predict GC survival, likely through transcriptional and immunologic modulation, thereby nominating these variants as potential immune\u2010genetic biomarkers for GC prognosis and therapeutic stratification.\n                  <\/jats:p>","DOI":"10.1002\/mc.70125","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:55:26Z","timestamp":1778853326000},"page":"948-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potentially Functional Variants in\n                    <i>FCER1A<\/i>\n                    and\n                    <i>PLCG2<\/i>\n                    , Two B Cell\u2010Related Immune Genes Predict the Survival of Chinese Gastric Cancer Patients"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3683-8062","authenticated-orcid":false,"given":"Guang","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, and The Research Institute for Cancer Control and Prevention, Greater Bay Area Institute of Precision Medicine (Guangzhou) Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5459-9472","authenticated-orcid":false,"given":"Guoqiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, and The Research Institute for Cancer Control and Prevention, Greater Bay Area Institute of Precision Medicine (Guangzhou) Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Global Health, School of Public Health Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanlin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Gastric Surgery Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University Shanghai China"},{"name":"Cancer Institute Fudan University Shanghai Cancer Center Shanghai 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