{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:30:48Z","timestamp":1786559448862,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303594"],"award-info":[{"award-number":["82303594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Oxaliplatin\u2010based chemotherapy is a principal treatment for colon cancer, but drug resistance hinders its efficacy. Cancer cell dormancy is reportedly a crucial driver of chemoresistance. IL\u201024 functions vitally in tumor chemoresistance, yet its role in colon cancer dormancy and oxaliplatin resistance remains unexplored.IL\u201024 expression was assessed in colon cancer tissues and cells via RT\u2010qPCR, western blotting, or immunohistochemistry. The functions of IL\u201024 in colon cancer cell proliferation, apoptosis, dormancy, and oxaliplatin resistance were evaluated by CCK\u20108, flow cytometry, and western blotting. The downstream mechanism of IL\u201024 was predicted using RNA sequencing and bioinformatics analyses and verified in vitro. A tumor xenograft mouse model was built to further verify the role of IL\u201024 in colon cancer. IL\u201024 was overexpressed in oxaliplatin\u2010resistant colon cancer tissues and cells. Furthermore, IL\u201024 treatment reversed the anti\u2010proliferative and pro\u2010apoptotic effects of oxaliplatin on colon cancer cells. Regarding cell dormancy, IL\u201024 treatment triggered G0\/G1 cell cycle arrest and upregulated dormancy markers (CDKN1A, CDKN1B, TGFB2, and MSK1). Bioinformatics analyses revealed that IL\u201024 might function in colon cancer mainly through NF\u2010\u03baB pathway, and IL\u201024 activated the NF\u2010\u03baB axis in tumor cells. Importantly, treatment with NF\u2010\u03baB inhibitor reversed IL\u201024\u2010induced colon cancer cell dormancy and oxaliplatin resistance. In vivo, IL\u201024 treatment abolished the anti\u2010tumor effects of oxaliplatin, promoted cell dormancy, and activated NF\u2010\u03baB signaling in tumor tissues. IL\u201024 induces colon cancer cell dormancy and oxaliplatin resistance by activating NF\u2010\u03baB signaling. The IL\u201024\/NF\u2010\u03baB axis may serve as a likely target to alleviate oxaliplatin resistance in colon cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mc.70147","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:21:18Z","timestamp":1784226078000},"page":"1126-1139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["IL\u201024 Induces Cell Dormancy and Oxaliplatin Resistance in Colon Cancer Cells by Activating NF\u2010\u03baB Pathway"],"prefix":"10.1002","volume":"65","author":[{"given":"Yanyan","family":"Hu","sequence":"first","affiliation":[{"name":"Clinical Laboratory Sanmen People's Hospital Sanmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengying","family":"Li","sequence":"additional","affiliation":[{"name":"Office of Drug Clinical Trial Institutions, Taizhou Hospital of Zhejiang Province Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Sanmen People's Hospital Sanmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8058-4194","authenticated-orcid":false,"given":"Chaoju","family":"Gong","sequence":"additional","affiliation":[{"name":"Central Laboratory, The Affiliated Xuzhou Municipal Hospital Xuzhou Medical University Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejun","family":"Fang","sequence":"additional","affiliation":[{"name":"Central Laboratory Sanmen People's Hospital Sanmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338231178403"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001175"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.69424"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338231206003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400663"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2022.101914"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i33.3810"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2023.468"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1567"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-03025-y"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1854"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04606-1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030768"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2019.06.001"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2018.12.002"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.05.010"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2695"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4622"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.08.008"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1843"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.6002"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0623-y"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6020044"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00902-6"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27227774"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11102057"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01359-y"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds236"},{"issue":"2","key":"e_1_2_12_31_1","article-title":"Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology","volume":"22","author":"Benson A. 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