{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:51:18Z","timestamp":1789487478478,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oral squamous cell carcinoma (OSCC) exhibits high recurrence rates, and immune escape within the tumor microenvironment is a critical barrier to effective therapy. This study investigates whether cancer\u2010associated fibroblast (CAF)\u2010derived FGF7 promotes immune escape in OSCC through JAK\/STAT3 pathway\u2010mediated PD\u2010L1. Tumor and adjacent tissues from OSCC patients were analyzed for FGFF7 expression, and the correlations between FGF7 and clinicopathological features were analyzed. CAFs were isolated from OSCC, transfected with plasmids targeting FGF7, and assessed for activation markers, 3D spheroid formation, and epithelial\u2010mesenchymal transition (EMT) proteins. Co\u2010culture systems were established to evaluate the malignant behaviors of OSCC cells exposed to modified CAFs through proliferation, migration, invasion, and apoptosis assays. OSCC cells were co\u2010cultured with CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, followed by measurement of JAK\/STAT3 phosphorylation, PD\u2010L1 expression, T\u2010cell activation markers, and immune\u2010related genes. In vivo effects were examined in xenograft models. FGF7 was overexpressed in OSCC tissues and cells, primarily originating from CAFs. FGF7 knockdown in CAFs suppressed activation markers, EMT, and malignant behaviors of OSCC cells. Mechanistically, FGF7 knockdown reduced JAK\/STAT3 phosphorylation and PD\u2010L1 expression, impairing T\u2010cell cytotoxicity and antigen presentation. A specific STAT3 inhibitor completely reversed FGF7\u2010induced PD\u2010L1 upregulation. ChIP\u2010qPCR confirmed that STAT3 directly binds to the PD\u2010L1 promoter and activates its transcription. In vivo, CAF\u2010specific FGF7 knockdown attenuated tumor growth and collagen deposition while increasing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell infiltration and apoptosis. Combined FGF7 knockdown and anti\u2010PD\u2010L1 therapy synergistically enhanced these effects. CAF\u2010derived FGF7 drives immune escape and OSCC progression by upregulating PD\u2010L1 via JAK\/STAT3 signaling.\n                  <\/jats:p>","DOI":"10.1002\/mc.70152","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T14:15:21Z","timestamp":1785593721000},"page":"1226-1243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer\u2010Associated Fibroblast\u2010Derived FGF7 Promotes Immune Escape in Oral Squamous Cell Carcinoma via JAK\/STAT3\u2010Mediated PD\u2010L1 Expression"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2887-2726","authenticated-orcid":false,"given":"Qinghua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Stomatology Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8238-9780","authenticated-orcid":false,"given":"Dongbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Stomatology Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155489"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-023-00249-w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04028-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105451"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12111807"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-021-01082-w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1485174"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25021300"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00048.2019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15275"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.686337"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01761-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225796"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14933"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13151294"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008414"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.690869"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-22-0896"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12420"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15174303"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12484"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13274"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00582-1"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00652"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.18053\/jctres.08.202201.007"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2024.100801"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13221824"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1524606"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05085-y"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01428-1"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020964"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2020.101417"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.slast.2025.100271"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.590"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15040126"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-024-04266-3"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.202300596"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-3677"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mc.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:29:08Z","timestamp":1789482548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mc.70152"],"URL":"https:\/\/doi.org\/10.1002\/mc.70152","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,1]]},"assertion":[{"value":"2026-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}