{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:42:22Z","timestamp":1789486942297,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073253"],"award-info":[{"award-number":["82073253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lung cancer remains one of the most commonly diagnosed cancers and the leading cause of cancer\u2010related mortality worldwide. As a mitochondrial matrix protein, the role of \u03b2\u2010lactamase\u2010like protein 2 (LACTB2) is unclear in non\u2010small cell lung cancer (NSCLC). In this study, we show that LACTB2 expression enhances the cell viability, anchorage\u2010independent growth, migration and epithelial\u2010mesenchymal transition(EMT) of NSCLC cells. Mechanistically, LACTB2 binds to mitochondrial DNA (mtDNA) and activates mitochondrial RNA (mtRNA) expression. Silencing LACTB2 induces mitochondrial dysfunction, which correlates with impaired proliferation, migration, and EMT in NSCLC cells. Furthermore, depletion of LACTB2 results in an increased expression of p53 and cleaved\u2010PARP, indicating that LACTB2\u2010mediated mitochondrial dysfunction activates the mitochondrial retrograde signaling\u2010p53 pathway to regulate apoptosis in A549 cells. Additionally, we found that high LACTB2 expression is statistically correlated with poor overall survival in NSCLC patients, and silencing LACTB2 inhibits tumor growth in xenograft mouse models. In summary, our findings reveal that LACTB2 plays a critical role in NSCLC progression by modulating mtRNA expression and mitochondrial function. Therefore, the LACTB2\u2010mtDNA\u2010mitochondrial dysfunction axis may serve as a novel target for diagnosis and treatment of NSCLC.<\/jats:p>","DOI":"10.1002\/mc.70180","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:38:09Z","timestamp":1789479489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LACTB2 Promotes the Growth and Migration of Non\u2010Small Cell Lung Cancer By Regulating Mitochondrial Function"],"prefix":"10.1002","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Sciences and Medical Engineering Anhui University Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering Anhui University Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering Anhui University Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Han","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering Anhui University Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4681-263X","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Medical Engineering Anhui University Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"7689","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature25183","article-title":"The Biology and Management of Non\u2010Small Cell Lung Cancer","volume":"553","author":"Herbst R. 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