{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:56:46Z","timestamp":1790535406904,"version":"4.1.0"},"reference-count":119,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA142604"],"award-info":[{"award-number":["R01 CA142604"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and\/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile. Root extract of\n                    <jats:italic>Withania somnifera<\/jats:italic>\n                    (Ashwagandha) is a key ingredient in Ayurvedic medicine practiced in India for thousands of years. Preclinical research has established that withaferin A (WA) is primarily responsible for the anticancer effect of Ashwagandha. At cellular level, WA treatment inhibits the growth of human breast cancer cells by causing G\n                    <jats:sub>2<\/jats:sub>\n                    \/M phase cell cycle arrest and apoptosis induction and suppressing the self\u2010renewal of breast cancer stem\u2010like cells. On the other hand, normal mammary epithelial cells are resistant to apoptosis induction by WA, which is a desirable characteristic of cancer preventive interventions. More importantly, WA administration prevents luminal type, human epidermal growth factor receptor 2\u2010driven, and basal\u2010like breast cancer development in rodents without causing any side effects. This review article not only succinctly summarizes preclinical evidence for anticancer effects of WA but also conceptualizes on high\u2010risk women and men who may benefit from Ashwagandha intervention for prevention of early onset of breast cancer or prevention of bone metastasis of breast cancer.\n                  <\/jats:p>","DOI":"10.1002\/mc.70186","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:31:06Z","timestamp":1790533866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevention of Early Onset of Breast Cancer With Ashwagandha"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-4575","authenticated-orcid":false,"given":"Eun\u2010Ryeong","family":"Hahm","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Hyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3733-144X","authenticated-orcid":false,"given":"Shivendra V.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA"},{"name":"UPMC Hillman Cancer Center University of Pittsburgh Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"issue":"4","key":"e_1_2_15_2_1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","article-title":"Global Patterns and Trends in Breast Cancer Incidence and Mortality Across 185 Countries","volume":"31","author":"Kim J.","year":"2025","journal-title":"Nature Medicine"},{"issue":"9","key":"e_1_2_15_3_1","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/jwh.2021.0113","article-title":"Breast Cancer in Black Women: Racial\/Ethnic Disparities Affecting Survival","volume":"31","author":"Nnorom S. O.","year":"2022","journal-title":"Journal of Women's Health"},{"issue":"6","key":"e_1_2_15_4_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5604\/01.3001.0016.3174","article-title":"Male Breast Cancer (MBC) \u2013 A Review","volume":"95","author":"AlFehaid M.","year":"2023","journal-title":"Polish Journal of Surgery"},{"issue":"4","key":"e_1_2_15_5_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2174\/0115665240349468241113065031","article-title":"An Overview of Invasive Ductal Carcinoma (IDC) in Women's Breast Cancer","volume":"25","author":"Gallas A. E.","year":"2025","journal-title":"Current Molecular Medicine"},{"issue":"2","key":"e_1_2_15_6_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10549-022-06572-w","article-title":"Invasive Lobular Carcinoma: An Understudied Emergent Subtype of Breast Cancer","volume":"193","author":"Mouabbi J. A.","year":"2022","journal-title":"Breast Cancer Research and Treatment"},{"issue":"2","key":"e_1_2_15_7_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1053\/ctrv.1999.0149","article-title":"Ductal Carcinoma In Situ (DCIS) of the Breast: Evolving Perspectives","volume":"26","author":"Sakorafas G. H.","year":"2000","journal-title":"Cancer Treatment Reviews"},{"issue":"1","key":"e_1_2_15_8_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41379-020-00689-3","article-title":"Lobular Carcinoma In Situ: Diagnostic Criteria and Molecular Correlates","volume":"34","author":"Sokolova A.","year":"2021","journal-title":"Modern Pathology"},{"issue":"6797","key":"e_1_2_15_9_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular Portraits of Human Breast Tumours","volume":"406","author":"Perou C. M.","year":"2000","journal-title":"Nature"},{"issue":"4","key":"e_1_2_15_10_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cpet.2023.04.002","article-title":"Molecular Classification of Breast Cancer","volume":"18","author":"Roy M.","year":"2023","journal-title":"PET Clinics"},{"issue":"10087","key":"e_1_2_15_11_1","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/S0140-6736(16)32417-5","article-title":"HER2\u2010Positive Breast Cancer","volume":"389","author":"Loibl S.","year":"2017","journal-title":"Lancet"},{"issue":"2","key":"e_1_2_15_12_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00404-015-3859-y","article-title":"An Overview of Triple\u2010Negative Breast Cancer","volume":"293","author":"Kumar P.","year":"2016","journal-title":"Archives of Gynecology and Obstetrics"},{"issue":"1","key":"e_1_2_15_13_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10549-018-4921-9","article-title":"Male Breast Cancer: A Disease Distinct From Female Breast Cancer","volume":"173","author":"Gucalp A.","year":"2019","journal-title":"Breast Cancer Research and Treatment"},{"key":"e_1_2_15_14_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/bs.ircmb.2023.11.002","article-title":"Inflammatory Breast Cancer Biomarkers and Biology","volume":"384","author":"Van Golen K. L.","year":"2024","journal-title":"International Review of Cell and Molecular Biology"},{"issue":"1","key":"e_1_2_15_15_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2022.0439","article-title":"Paget's Disease of the Breast: Diagnosis and Management","volume":"84","author":"Hudson\u2010Phillips S.","year":"2023","journal-title":"British Journal of Hospital Medicine"},{"issue":"1","key":"e_1_2_15_16_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/his.12876","article-title":"Phyllodes Tumours of the Breast: A Consensus Review","volume":"68","author":"Tan B. Y.","year":"2016","journal-title":"Histopathology"},{"issue":"2","key":"e_1_2_15_17_1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/phn.13504","article-title":"Modifiable Risk Factors for Breast Cancer: Insights From Systematic Reviews","volume":"42","author":"Li X.","year":"2025","journal-title":"Public Health Nursing"},{"issue":"4","key":"e_1_2_15_18_1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.23736\/S2724-5691.25.10651-5","article-title":"Current Insights Into Breast and Ovarian Cancer Risk: A Contemporary Review","volume":"80","author":"Gaughan N. A.","year":"2025","journal-title":"Minerva Surgery"},{"issue":"1","key":"e_1_2_15_19_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1186\/s12885-023-11049-0","article-title":"Association of Reproductive Risk Factors and Breast Cancer Molecular Subtypes: A Systematic Review and Meta\u2010Analysis","volume":"23","author":"Mao X.","year":"2023","journal-title":"BMC Cancer"},{"issue":"4","key":"e_1_2_15_20_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.rcl.2023.12.014","article-title":"Hereditary Breast Cancer","volume":"62","author":"Patel M. M.","year":"2024","journal-title":"Radiologic Clinics of North America"},{"issue":"21","key":"e_1_2_15_21_1","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1002\/cncr.32345","article-title":"ESR1 Mutations in Breast Cancer","volume":"125","author":"Dustin D.","year":"2019","journal-title":"Cancer"},{"issue":"4","key":"e_1_2_15_22_1","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.18632\/aging.102783","article-title":"Comparison of BRCA Versus Non\u2010BRCA Germline Mutations and Associated Somatic Mutation Profiles in Patients With Unselected Breast Cancer","volume":"12","author":"Chen B.","year":"2020","journal-title":"Aging"},{"issue":"18","key":"e_1_2_15_23_1","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","article-title":"Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P\u20101 Study","volume":"90","author":"Fisher B.","year":"1998","journal-title":"Journal of the National Cancer Institute"},{"issue":"3","key":"e_1_2_15_24_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.pharmthera.2013.05.005","article-title":"Toxicity and Adverse Effects of Tamoxifen and Other Anti\u2010Estrogen Drugs","volume":"139","author":"Yang G.","year":"2013","journal-title":"Pharmacology & Therapeutics"},{"issue":"25","key":"e_1_2_15_25_1","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1056\/NEJMoa1103507","article-title":"Exemestane for Breast\u2010Cancer Prevention in Postmenopausal Women","volume":"364","author":"Goss P. E.","year":"2011","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"e_1_2_15_26_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13643-018-0854-y","article-title":"Herceptin\u00ae (Trastuzumab) in HER2\u2010Positive Early Breast Cancer: A Systematic Review and Cumulative Network Meta\u2010Analysis","volume":"7","author":"Wilson F. R.","year":"2018","journal-title":"Systematic Reviews"},{"issue":"2","key":"e_1_2_15_27_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/19390211.2020.1741484","article-title":"Pharmacological Evaluation of Ashwagandha Highlighting Its Healthcare Claims, Safety, and Toxicity Aspects","volume":"18","author":"Mandlik (Ingawale) D. S.","year":"2021","journal-title":"Journal of Dietary Supplements"},{"issue":"5","key":"e_1_2_15_28_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/elps.202400188","article-title":"Determination of Withanolides and Withanosides in Ashwagandha Based Products Using HPLC\u2010Drift\u2010Tube\u2010Ion\u2010Mobility Quadrupole Time\u2010of\u2010Flight Mass Spectrometry","volume":"46","author":"Zellner L.","year":"2025","journal-title":"Electrophoresis"},{"issue":"11","key":"e_1_2_15_29_1","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s00262-013-1470-2","article-title":"Myeloid\u2010Derived Suppressor Cell Function Is Reduced by Withaferin A, a Potent and Abundant Component of Withania somnifera Root Extract","volume":"62","author":"Sinha P.","year":"2013","journal-title":"Cancer Immunology, Immunotherapy"},{"issue":"3","key":"e_1_2_15_30_1","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1074\/jbc.M113.496844","article-title":"Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated With Down\u2010Regulation and Covalent Binding at Cysteine 303 of \u03b2\u2010Tubulin","volume":"289","author":"Antony M. L.","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"11","key":"e_1_2_15_31_1","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1002\/ijc.25938","article-title":"Withaferin A Inhibits Breast Cancer Invasion and Metastasis at Sub\u2010Cytotoxic Doses by Inducing Vimentin Disassembly and Serine 56 Phosphorylation","volume":"129","author":"Thaiparambil J. T.","year":"2011","journal-title":"International Journal of Cancer"},{"issue":"2","key":"e_1_2_15_32_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1124\/jpet.119.256792","article-title":"Withaferin A Improves Nonalcoholic Steatohepatitis in Mice","volume":"371","author":"Patel D. P.","year":"2019","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"8","key":"e_1_2_15_33_1","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.294","article-title":"Withaferin A: A Proteasomal Inhibitor Promotes Healing After Injury and Exerts Anabolic Effect on Osteoporotic Bone","volume":"4","author":"Khedgikar V.","year":"2013","journal-title":"Cell Death & Disease"},{"issue":"8","key":"e_1_2_15_34_1","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4573","article-title":"Studies on Oral Bioavailability and First\u2010Pass Metabolism of Withaferin A in Rats Using LC\u2010MS\/MS and Q\u2010TRAP","volume":"33","author":"Dai T.","year":"2019","journal-title":"Biomedical Chromatography"},{"key":"e_1_2_15_35_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jchromb.2019.05.016","article-title":"Liquid Chromatography\u2010Tandem Mass Spectrometry to Assess the Pharmacokinetics and Tissue Distribution of Withaferin A in Rats","volume":"1122","author":"Wang F.","year":"2019","journal-title":"Journal of Chromatography B"},{"issue":"6","key":"e_1_2_15_36_1","doi-asserted-by":"crossref","first-page":"djw293","DOI":"10.1093\/jnci\/djw293","article-title":"Disease Subtype\u2010Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A","volume":"109","author":"Samanta S. K.","year":"2016","journal-title":"Journal of the National Cancer Institute"},{"issue":"1","key":"e_1_2_15_37_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jaim.2018.12.008","article-title":"Safety and Pharmacokinetics of Withaferin\u2010A in Advanced Stage High Grade Osteosarcoma: A Phase I Trial","volume":"11","author":"Pires N.","year":"2020","journal-title":"Journal of Ayurveda and Integrative Medicine"},{"issue":"4","key":"e_1_2_15_38_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4103\/0253-7613.115012","article-title":"Effects of Withania somnifera in Patients of Schizophrenia: A Randomized, Double Blind, Placebo Controlled Pilot Trial Study","volume":"45","author":"Agnihotri A.","year":"2013","journal-title":"Indian Journal of Pharmacology"},{"key":"e_1_2_15_39_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117603","article-title":"Clinical Pharmacokinetic Evaluation of Withania somnifera (L.) Dunal Root Extract in Healthy Human Volunteers: A Non\u2010Randomized, Single Dose Study Utilizing UHPLC\u2010MS\/MS Analysis","volume":"322","author":"Vaidya V. G.","year":"2024","journal-title":"Journal of Ethnopharmacology"},{"issue":"1","key":"e_1_2_15_40_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/01635580802381477","article-title":"Ayurvedic Medicine Constituent Withaferin A Causes G2 and M Phase Cell Cycle Arrest in Human Breast Cancer Cells","volume":"60","author":"Stan S. D.","year":"2008","journal-title":"Nutrition and Cancer"},{"issue":"11","key":"e_1_2_15_41_1","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/mc.23104","article-title":"Withaferin A Inhibits Expression of Ataxia Telangiectasia and Rad3\u2010Related Kinase and Enhances Sensitivity of Human Breast Cancer Cells to Cisplatin","volume":"58","author":"Hahm E. R.","year":"2019","journal-title":"Molecular Carcinogenesis"},{"issue":"7","key":"e_1_2_15_42_1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/mc.22814","article-title":"Peptidyl\u2010Prolyl Cis\/Trans Isomerase Pin1 Regulates Withaferin A\u2010Mediated Cell Cycle Arrest in Human Breast Cancer Cells","volume":"57","author":"Samanta S. K.","year":"2018","journal-title":"Molecular Carcinogenesis"},{"issue":"4","key":"e_1_2_15_43_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1158\/1940-6207.CAPR-20-0590","article-title":"The Role of Forkhead Box Q1 Transcription Factor in Anticancer Effects of Withaferin A in Breast Cancer","volume":"14","author":"Kim S. H.","year":"2021","journal-title":"Cancer Prevention Research"},{"issue":"1","key":"e_1_2_15_44_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/metabo13010029","article-title":"Natural Steroidal Lactone Induces G1\/S Phase Cell Cycle Arrest and Intrinsic Apoptotic Pathway by Up\u2010Regulating Tumor Suppressive miRNA in Triple\u2010Negative Breast Cancer Cells","volume":"13","author":"Shuaib M.","year":"2022","journal-title":"Metabolites"},{"issue":"18","key":"e_1_2_15_45_1","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1158\/0008-5472.CAN-08-1510","article-title":"Withaferin A Causes FOXO3a\u2010 and Bim\u2010Dependent Apoptosis and Inhibits Growth of Human Breast Cancer Cells In Vivo","volume":"68","author":"Stan S. D.","year":"2008","journal-title":"Cancer Research"},{"issue":"8","key":"e_1_2_15_46_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023354","article-title":"Withaferin A\u2010Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species","volume":"6","author":"Hahm E. R.","year":"2011","journal-title":"PLoS One"},{"key":"e_1_2_15_47_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.mito.2019.01.003","article-title":"Withaferin A\u2010Mediated Apoptosis in Breast Cancer Cells Is Associated With Alterations in Mitochondrial Dynamics","volume":"47","author":"Sehrawat A.","year":"2019","journal-title":"Mitochondrion"},{"issue":"12","key":"e_1_2_15_48_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168488","article-title":"Withaferin A Induces ROS\u2010Mediated Paraptosis in Human Breast Cancer Cell\u2010Lines MCF\u20107 and MDA\u2010MB\u2010231","volume":"11","author":"Ghosh K.","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"e_1_2_15_49_1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/carcin\/bgz015","article-title":"Withaferin A Inhibits Lysosomal Activity to Block Autophagic Flux and Induces Apoptosis via Energetic Impairment in Breast Cancer Cells","volume":"40","author":"Muniraj N.","year":"2019","journal-title":"Carcinogenesis"},{"issue":"1","key":"e_1_2_15_50_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.canlet.2012.08.026","article-title":"Withaferin A\u2010Induced Apoptosis in Human Breast Cancer Cells Is Associated With Suppression of Inhibitor of Apoptosis Family Protein Expression","volume":"334","author":"Hahm E. R.","year":"2013","journal-title":"Cancer Letters"},{"issue":"11","key":"e_1_2_15_51_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/mc.22050","article-title":"Role of Mitogen\u2010Activated Protein Kinases and Mcl\u20101 in Apoptosis Induction by Withaferin A in Human Breast Cancer Cells","volume":"53","author":"Hahm E. R.","year":"2014","journal-title":"Molecular Carcinogenesis"},{"issue":"8","key":"e_1_2_15_52_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/mc.20760","article-title":"Withaferin A Suppresses Estrogen Receptor\u2010\u03b1 Expression in Human Breast Cancer Cells","volume":"50","author":"Hahm E. R.","year":"2011","journal-title":"Molecular Carcinogenesis"},{"key":"e_1_2_15_53_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1472-6882-11-84","article-title":"Down\u2010Regulation of Estrogen Receptor\u2010Alpha and Rearranged During Transfection Tyrosine Kinase Is Associated With Withaferin A\u2010Induced Apoptosis in MCF\u20107 Breast Cancer Cells","volume":"11","author":"Zhang X.","year":"2011","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"9","key":"e_1_2_15_54_1","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1158\/0008-5472.CAN-13-2081","article-title":"Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer","volume":"74","author":"Nagalingam A.","year":"2014","journal-title":"Cancer Research"},{"issue":"2","key":"e_1_2_15_55_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/jcm5020013","article-title":"Epithelial\u2010Mesenchymal Transition and Breast Cancer","volume":"5","author":"Wu Y.","year":"2016","journal-title":"Journal of Clinical Medicine"},{"issue":"9","key":"e_1_2_15_56_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075069","article-title":"Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition","volume":"8","author":"Yang Z.","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"e_1_2_15_57_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/mc.22110","article-title":"Withaferin A Inhibits Experimental Epithelial\u2010Mesenchymal Transition in MCF\u201010A Cells and Suppresses Vimentin Protein Level In Vivo in Breast Tumors","volume":"54","author":"Lee J.","year":"2015","journal-title":"Molecular Carcinogenesis"},{"issue":"2","key":"e_1_2_15_58_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/ijms26020493","article-title":"Molecular Characterization of Cancer Preventive and Therapeutic Potential of Three Antistress Compounds, Triethylene Glycol, Withanone, and Withaferin A","volume":"26","author":"Zhang H.","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.70131"},{"issue":"1","key":"e_1_2_15_60_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10549-012-2239-6","article-title":"Withaferin A Causes Activation of Notch2 and Notch4 in Human Breast Cancer Cells","volume":"136","author":"Lee J.","year":"2012","journal-title":"Breast Cancer Research and Treatment"},{"issue":"11","key":"e_1_2_15_61_1","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1093\/carcin\/bgq175","article-title":"Withaferin A Inhibits Activation of Signal Transducer and Activator of Transcription 3 in Human Breast Cancer Cells","volume":"31","author":"Lee J.","year":"2010","journal-title":"Carcinogenesis"},{"key":"e_1_2_15_62_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biocel.2018.12.001","article-title":"Breast Cancer Stem Cells: Biology and Therapeutic Implications","volume":"107","author":"Butti R.","year":"2019","journal-title":"International Journal of Biochemistry & Cell Biology"},{"issue":"7","key":"e_1_2_15_63_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1158\/1940-6207.CAPR-13-0445","article-title":"Mammary Cancer Chemoprevention by Withaferin A Is Accompanied by In Vivo Suppression of Self\u2010Renewal of Cancer Stem Cells","volume":"7","author":"Kim S. H.","year":"2014","journal-title":"Cancer Prevention Research"},{"issue":"8","key":"e_1_2_15_64_1","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.cell.2025.12.049","article-title":"Hallmarks of Cancer\u2010Then and Now, and Beyond","volume":"189","author":"Hanahan D.","year":"2026","journal-title":"Cell"},{"issue":"1","key":"e_1_2_15_65_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mc.23266","article-title":"RNA\u2010Seq Reveals Novel Cancer\u2010Selective and Disease Subtype\u2010Independent Mechanistic Targets of Withaferin A in Human Breast Cancer Cells","volume":"60","author":"Hahm E. R.","year":"2021","journal-title":"Molecular Carcinogenesis"},{"issue":"1","key":"e_1_2_15_66_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1158\/1940-6207.CAPR-22-0193","article-title":"Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors","volume":"16","author":"Singh K. B.","year":"2023","journal-title":"Cancer Prevention Research"},{"issue":"1","key":"e_1_2_15_67_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-72221-5","article-title":"Withaferin A Decreases Glycolytic Reprogramming in Breast Cancer","volume":"14","author":"Khan A.","year":"2024","journal-title":"Scientific Reports"},{"key":"e_1_2_15_68_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1401113","article-title":"Molecular Mechanism of Bone Metastasis in Breast Cancer","volume":"14","author":"Sui L.","year":"2024","journal-title":"Frontiers in Oncology"},{"issue":"5","key":"e_1_2_15_69_1","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1194\/jlr.M800626-JLR200","article-title":"Saturated Fatty Acids Enhance Osteoclast Survival","volume":"51","author":"Oh S. R.","year":"2010","journal-title":"Journal of Lipid Research"},{"issue":"7","key":"e_1_2_15_70_1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/mc.23545","article-title":"Withaferin A Inhibits Breast Cancer\u2010Induced Osteoclast Differentiation","volume":"62","author":"Hahm E. R.","year":"2023","journal-title":"Molecular Carcinogenesis"},{"key":"e_1_2_15_71_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fcell.2020.00076","article-title":"RANKL\/RANK System\u2010Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies","volume":"8","author":"Wu X.","year":"2020","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"e_1_2_15_72_1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ijbiomac.2017.03.021","article-title":"Role of Runx2 in Breast Cancer\u2010Mediated Bone Metastasis","volume":"99","author":"Vishal M.","year":"2017","journal-title":"International Journal of Biological Macromolecules"},{"issue":"6","key":"e_1_2_15_73_1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2174\/15680096113139990039","article-title":"Autophagy Fails to Alter Withaferin A\u2010Mediated Lethality in Human Breast Cancer Cells","volume":"13","author":"Hahm E. R.","year":"2013","journal-title":"Current Cancer Drug Targets"},{"key":"e_1_2_15_74_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.tiv.2017.07.025","article-title":"Withaferin A Induced Impaired Autophagy and Unfolded Protein Response in Human Breast Cancer Cell\u2010Lines MCF\u20107 and MDA\u2010MB\u2010231","volume":"44","author":"Ghosh K.","year":"2017","journal-title":"Toxicology In Vitro"},{"key":"e_1_2_15_75_1","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/707586","article-title":"Withaferin A Induces Proteasome\u2010Dependent Degradation of Breast Cancer Susceptibility Gene 1 and Heat Shock Factor 1 Proteins in Breast Cancer Cells","volume":"2012","author":"Zhang X.","year":"2012","journal-title":"ISRN Biochemistry"},{"issue":"9","key":"e_1_2_15_76_1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/mc.23440","article-title":"Withaferin A Mediated Changes of miRNA Expression in Breast Cancer\u2010Derived Mammospheres","volume":"61","author":"Prajapati K. S.","year":"2022","journal-title":"Molecular Carcinogenesis"},{"issue":"1","key":"e_1_2_15_77_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast Cancer: Pathogenesis and Treatments","volume":"10","author":"Xiong X.","year":"2025","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"2","key":"e_1_2_15_78_1","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbae032","article-title":"Integrating Network Pharmacology and In Silico Analysis Deciphers Withaferin\u2010A's Anti\u2010Breast Cancer Potential via Hedgehog Pathway and Target Network Interplay","volume":"25","author":"Srinivasan M.","year":"2024","journal-title":"Briefings in Bioinformatics"},{"key":"e_1_2_15_79_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.phymed.2018.09.017","article-title":"Different Effects of 4\u03b2\u2010Hydroxywithanolide E and Withaferin A, Two Withanolides From Solanaceae Plants, on the Akt Signaling Pathway in Human Breast Cancer Cells","volume":"53","author":"Wang H. C.","year":"2019","journal-title":"Phytomedicine"},{"issue":"11","key":"e_1_2_15_80_1","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1158\/1535-7163.MCT-15-0932","article-title":"ERBB2 Overexpression Establishes ERBB3\u2010Dependent Hypersensitivity of Breast Cancer Cells to Withaferin A","volume":"15","author":"Liu W.","year":"2016","journal-title":"Molecular Cancer Therapeutics"},{"issue":"6","key":"e_1_2_15_81_1","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1038\/s41401-024-01468-5","article-title":"Chemoproteomics Reveals Proteome\u2010Wide Covalent and Non\u2010Covalent Targets of Withaferin A","volume":"46","author":"Nie H.","year":"2025","journal-title":"Acta Pharmacologica Sinica"},{"issue":"1","key":"e_1_2_15_82_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12906-021-03340-z","article-title":"A Systems Pharmacology Approach Based on Oncogenic Signalling Pathways to Determine the Mechanisms of Action of Natural Products in Breast Cancer From Transcriptome Data","volume":"21","author":"Odongo R.","year":"2021","journal-title":"BMC Complementary Medicine and Therapies"},{"key":"e_1_2_15_83_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152332","article-title":"Integrated Transcriptome Analysis and In Silico Investigations Identify KHDRBS3 to Target With Steroidal Lactone in Paclitaxel Resistance Breast Cancer","volume":"777","author":"Sarkar T.","year":"2025","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"20","key":"e_1_2_15_84_1","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1128\/MCB.01657-08","article-title":"Hyperactivated NF\u2010\u03baB and AP\u20101 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription Across the Interleukin\u20106 Gene Promoter in Metastatic Breast Cancer Cells","volume":"29","author":"Ndlovu M. N.","year":"2009","journal-title":"Molecular and Cellular Biology"},{"issue":"1","key":"e_1_2_15_85_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4048\/jbc.2013.16.1.23","article-title":"Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins","volume":"16","author":"Mirza S.","year":"2013","journal-title":"Journal of Breast Cancer"},{"issue":"3","key":"e_1_2_15_86_1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3390\/ijms26031210","article-title":"p21 Promoter Methylation Is Vital for the Anticancer Activity of Withaferin A","volume":"26","author":"Brane A.","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"issue":"11","key":"e_1_2_15_87_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113783","article-title":"Tumor Necrosis Factor\u2010\u03b1 Sensitizes Breast Cancer Cells to Natural Products With Proteasome\u2010Inhibitory Activity Leading to Apoptosis","volume":"9","author":"Lu L.","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"e_1_2_15_88_1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.chembiol.2017.08.013","article-title":"Covalent Ligand Discovery Against Druggable Hotspots Targeted by Anti\u2010Cancer Natural Products","volume":"24","author":"Grossman E. A.","year":"2017","journal-title":"Cell Chemical Biology"},{"issue":"6","key":"e_1_2_15_89_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.chembiol.2007.04.010","article-title":"The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin","volume":"14","author":"Bargagna\u2010Mohan P.","year":"2007","journal-title":"Chemistry & Biology"},{"issue":"6","key":"e_1_2_15_90_1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1124\/mol.119.117812","article-title":"The Natural Compound Withaferin A Covalently Binds to Cys239 of \u03b2\u2010Tubulin to Promote Tubulin Degradation","volume":"96","author":"Yang J.","year":"2019","journal-title":"Molecular Pharmacology"},{"issue":"48","key":"e_1_2_15_91_1","doi-asserted-by":"crossref","first-page":"33161","DOI":"10.1074\/jbc.M114.582478","article-title":"Covalent Modification of the NF\u2010\u03baB Essential Modulator (NEMO) by a Chemical Compound Can Regulate Its Ubiquitin Binding Properties In Vitro","volume":"289","author":"Hooper C.","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"e_1_2_15_92_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.taap.2015.09.014","article-title":"Thiol Dependent NF\u2010\u03baB Suppression and Inhibition of T\u2010Cell Mediated Adaptive Immune Responses by a Naturally Occurring Steroidal Lactone Withaferin A","volume":"289","author":"Gambhir L.","year":"2015","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"4","key":"e_1_2_15_93_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bcp.2009.09.017","article-title":"Withaferin A Targets Heat Shock Protein 90 in Pancreatic Cancer Cells","volume":"79","author":"Yu Y.","year":"2010","journal-title":"Biochemical Pharmacology"},{"key":"e_1_2_15_94_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110383","article-title":"Withaferin A Suppresses Breast Cancer Cell Proliferation by Inhibition of the Two\u2010Pore Domain Potassium (K2P9) Channel TASK\u20103","volume":"129","author":"Z\u00fa\u00f1iga R.","year":"2020","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"2","key":"e_1_2_15_95_1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/biom12020212","article-title":"Computational Identification of BCR\u2010ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone","volume":"12","author":"Malik V.","year":"2022","journal-title":"Biomolecules"},{"issue":"11","key":"e_1_2_15_96_1","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1080\/07391102.2022.2078410","article-title":"In\u2010Silico Validation of Novel Therapeutic Activities of Withaferin A Using Molecular Docking and Dynamics Studies","volume":"41","author":"Surya Ulhas R.","year":"2023","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"issue":"6","key":"e_1_2_15_97_1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/s41375-022-01554-9","article-title":"Identification of a c\u2010MYB\u2010Directed Therapeutic for Acute Myeloid Leukemia","volume":"36","author":"Clesham K.","year":"2022","journal-title":"Leukemia"},{"key":"e_1_2_15_98_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1199273","article-title":"MDSCs in Breast Cancer: An Important Enabler of Tumor Progression and an Emerging Therapeutic Target","volume":"14","author":"Liu H.","year":"2023","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"e_1_2_15_99_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.15430\/JCP.26.011","article-title":"Oral Administration of Withaferin A Increases Infiltration of CD4+ Helper T Cells in a Mouse Model of Mammary Tumor","volume":"31","author":"Hahm E. R.","year":"2026","journal-title":"Journal of Cancer Prevention"},{"key":"e_1_2_15_100_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/bs.pmbts.2017.07.003","article-title":"Association of Cytokines and Chemokines in Pathogenesis of Breast Cancer","volume":"151","author":"King J.","year":"2017","journal-title":"Progress in Molecular Biology and Translational Science"},{"issue":"1","key":"e_1_2_15_101_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10549-016-3795-y","article-title":"Withaferin A Inhibits In Vivo Growth of Breast Cancer Cells Accelerated by Notch2 Knockdown","volume":"157","author":"Kim S. H.","year":"2016","journal-title":"Breast Cancer Research and Treatment"},{"issue":"1","key":"e_1_2_15_102_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yexcr.2018.04.015","article-title":"Withaferin A and Sulforaphane Regulate Breast Cancer Cell Cycle Progression Through Epigenetic Mechanisms","volume":"368","author":"Royston K. J.","year":"2018","journal-title":"Experimental Cell Research"},{"issue":"5","key":"e_1_2_15_103_1","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.3390\/ijms18051092","article-title":"A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells","volume":"18","author":"Royston K.","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"e_1_2_15_104_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10456-004-1026-3","article-title":"Withaferin A Is a Potent Inhibitor of Angiogenesis","volume":"7","author":"Mohan R.","year":"2004","journal-title":"Angiogenesis"},{"issue":"15","key":"e_1_2_15_105_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/jnci\/djt153","article-title":"Metabolic Alterations in Mammary Cancer Prevention by Withaferin A in a Clinically Relevant Mouse Model","volume":"105","author":"Hahm E. R.","year":"2013","journal-title":"Journal of the National Cancer Institute"},{"issue":"3","key":"e_1_2_15_106_1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/bjc.2014.298","article-title":"Elevated Expression of Myosin X in Tumours Contributes to Breast Cancer Aggressiveness and Metastasis","volume":"111","author":"Cao R.","year":"2014","journal-title":"British Journal of Cancer"},{"issue":"2","key":"e_1_2_15_107_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/cdd.2016.122","article-title":"PIN1 in Breast Development and Cancer: A Clinical Perspective","volume":"24","author":"Rustighi A.","year":"2017","journal-title":"Cell Death & Differentiation"},{"issue":"2","key":"e_1_2_15_108_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00662142","article-title":"Nm23 and Breast Cancer Metastasis","volume":"25","author":"Steeg P. S.","year":"1993","journal-title":"Breast Cancer Research and Treatment"},{"issue":"10","key":"e_1_2_15_109_1","first-page":"5277","article-title":"Gelsolin Is Associated With Longer Metastasis\u2010Free Survival and Reduced Cell Migration in Estrogen Receptor\u2010Positive Breast Cancer","volume":"35","author":"Stock A. M.","year":"2015","journal-title":"Anticancer Research"},{"issue":"2","key":"e_1_2_15_110_1","first-page":"1921","article-title":"Moesin Is an Independent Prognostic Marker for ER\u2010Positive Breast Cancer","volume":"17","author":"Yu L.","year":"2019","journal-title":"Oncology Letters"},{"issue":"6","key":"e_1_2_15_111_1","doi-asserted-by":"crossref","DOI":"10.1111\/boc.202200110","article-title":"Annexin\u2010A5 and Annexin\u2010A6 Silencing Prevents Metastasis of Breast Cancer Cells in Zebrafish","volume":"115","author":"Gounou C.","year":"2023","journal-title":"Biology of the Cell"},{"issue":"4","key":"e_1_2_15_112_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.gendis.2024.101376","article-title":"Lipid Metabolism Involved in Progression and Drug Resistance of Breast Cancer","volume":"12","author":"Fu W.","year":"2024","journal-title":"Genes & Diseases"},{"issue":"20","key":"e_1_2_15_113_1","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1200\/JCO.2009.25.9820","article-title":"Metastatic Behavior of Breast Cancer Subtypes","volume":"28","author":"Kennecke H.","year":"2010","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"e_1_2_15_114_1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1373\/clinchem.2016.259085","article-title":"Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease","volume":"63","author":"Greenblatt M. B.","year":"2017","journal-title":"Clinical Chemistry"},{"issue":"12","key":"e_1_2_15_115_1","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1634\/theoncologist.2015-0527","article-title":"N\u2010Telopeptide of Type I Collagen Long\u2010Term Dynamics in Breast Cancer Patients With Bone Metastases: Clinical Outcomes and Influence of Extraskeletal Metastases","volume":"21","author":"Ferreira A. R.","year":"2016","journal-title":"Oncologist"},{"issue":"12","key":"e_1_2_15_116_1","first-page":"5277","article-title":"Study on Diagnostic Value of P1NP and \u03b2\u2010CTX in Bone Metastasis of Patients With Breast Cancer and the Correlation Between Them","volume":"23","author":"Zuo C. T.","year":"2019","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"20","key":"e_1_2_15_117_1","doi-asserted-by":"crossref","first-page":"6243s","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity","volume":"12","author":"Coleman R. E.","year":"2006","journal-title":"Clinical Cancer Research"},{"issue":"149","key":"e_1_2_15_118_1","first-page":"211","article-title":"Skeletal\u2010Related Adverse Events During Bone Metastasis of Breast Cancer: Current Status","volume":"27","author":"Yang M.","year":"2019","journal-title":"Discovery Medicine"},{"key":"e_1_2_15_119_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2022.01.015","article-title":"Tumor Microenvironment Mechanisms and Bone Metastatic Disease Progression of Prostate Cancer","volume":"530","author":"Kang J.","year":"2022","journal-title":"Cancer Letters"},{"issue":"6","key":"e_1_2_15_120_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jbspin.2017.05.006","article-title":"Pathophysiology of Bone Metastases From Solid Malignancies","volume":"84","author":"Cl\u00e9zardin P.","year":"2017","journal-title":"Joint Bone Spine"}],"container-title":["Molecular Carcinogenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.70186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mc.70186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mc.70186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:31:20Z","timestamp":1790533880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mc.70186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":119,"alternative-id":["10.1002\/mc.70186"],"URL":"https:\/\/doi.org\/10.1002\/mc.70186","archive":["Portico"],"relation":{},"ISSN":["0899-1987","1098-2744"],"issn-type":[{"value":"0899-1987","type":"print"},{"value":"1098-2744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"mc.70186"}}