{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:53:54Z","timestamp":1791298434887,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00cdfico e Tecnol\u00d3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00c7\u00c3o de Aperfei\u00c7oamento de Pessoal de N\u00cdvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00c7\u00c3o de Amparo \u00c0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neutrophil extracellular traps (NETs) and inflammatory mediators have been implicated in head and neck squamous cell carcinoma, but their relationship with systemic inflammatory status during radiotherapy remains incompletely understood. This exploratory integrative study combined a literature\u2010guided network\u2010based bioinformatic prioritization strategy, public transcriptomic interrogation, and a small serum\u2010based clinical cohort evaluated during radiotherapy. Network and ontology analyses identified IL6 and CXCL8 as central inflammatory mediators within a NET\u2010associated condition\u2010specific interaction network. Public transcriptomic analyses showed altered expression patterns of selected NETosis\u2010related genes in tumor tissue. To provide complementary clinical context, circulating NET\u2010associated complexes, interleukin\u20106 (IL\u20106), and interleukin\u20108 (IL\u20108) were measured in patients with head and neck squamous cell carcinoma undergoing radiotherapy and in healthy controls. Patients showed higher serum levels of NET\u2010associated complexes, IL\u20106, and IL\u20108 than controls, whereas no significant differences were observed between the two intra\u2010treatment sampling time points. These findings support the relevance of NET\u2010associated inflammatory markers in HNSCC and indicate that systemic inflammatory alterations can be detected in patients sampled during radiotherapy. Given the exploratory design and limited sample size, these findings should be interpreted cautiously and require validation in larger longitudinal studies.<\/jats:p>","DOI":"10.1002\/mc.70190","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:35:02Z","timestamp":1791297302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NET\u2010Associated Inflammatory Markers in Head and Neck Squamous Cell Carcinoma: Bioinformatic Prioritization and Exploratory Serum Assessment in Patients Undergoing Radiotherapy"],"prefix":"10.1002","author":[{"given":"Eloa Mangabeira","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Dentistry Universidade Estadual de Montes Claros (Unimontes) Montes Claros Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1050-5964","authenticated-orcid":false,"given":"Daniela Fernanda 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