{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:52:23Z","timestamp":1791899543315,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Carcinogenesis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Non\u2010small cell lung cancer (NSCLC) remains the leading cause of cancer\u2010related mortality worldwide. Ubiquitin\u2010specific protease 26 (USP26) has been implicated in tumor progression, but its functional role and molecular mechanism in NSCLC remain poorly understood. USP26 was significantly upregulated in NSCLC tissues and cell lines, correlating with poor prognosis. Functionally, USP26 promoted cell proliferation and colony formation while inhibiting apoptosis. Mechanistically, USP26 directly interacted with and deubiquitinated G\u03b1s, stabilizing it to activate the cAMP\/PKA signaling pathway. USP26 also suppressed autophagic flux and ER\u2010phagy, and its pro\u2010tumor effects were abrogated by the autophagy inhibitor 3\u2010MA. Our findings demonstrate that USP26 functions as an oncogenic driver in NSCLC by stabilizing G\u03b1s and suppressing autophagy, highlighting its potential as a prognostic biomarker and therapeutic target.<\/jats:p>","DOI":"10.1002\/mc.70194","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:16:37Z","timestamp":1791897397000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["USP26 Promotes Non\u2010Small Cell Lung Cancer Progression via Deubiquitination and Stabilization of G\u03b1s"],"prefix":"10.1002","author":[{"given":"Lifei","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Fujian Medical University Union Hospital Fuzhou China"},{"name":"Fujian Key Laboratory of Tumor Microbiology Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fujian Medical University Union Hospital Fuzhou China"},{"name":"Key Laboratory of Cardio\u2010Thoracic Surgery (Fujian Medical University) Fujian Province University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaimin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Tuling Biology Science and Technology Co. LTD Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5740-4802","authenticated-orcid":false,"given":"Wentao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqiang","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fujian Medical University Union Hospital Fuzhou China"},{"name":"Key Laboratory of Cardio\u2010Thoracic Surgery (Fujian Medical University) Fujian Province University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.56532"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01083-5"},{"key":"e_1_2_13_5_1","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.70050","article-title":"Mechanistic Insights and Therapeutic Potentials of Ubiquitin\u2010Proteasome System in Non\u2010small Cell Lung Cancer","volume":"58","author":"Zhou G.","year":"2025","journal-title":"Cell proliferation"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16164-1"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70391"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01080"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13112586"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04781-1"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2023-001878"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14799"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098638"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123288"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58682-w"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34015"},{"key":"e_1_2_13_17_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological Functions of Autophagy Genes: A Disease Perspective","volume":"176","author":"Levine B.","year":"2019","journal-title":"Cell"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215300"},{"key":"e_1_2_13_19_1","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1507","article-title":"Tcgabiolinks: An R\/Bioconductor Package for Integrative Analysis of TCGA Data","volume":"44","author":"Colaprico A.","year":"2016","journal-title":"Nucleic Acids Research"},{"key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated Estimation of Fold Change and Dispersion for RNA\u2010Seq Data With DESeq. 2","volume":"15","author":"Love M. 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