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However, most of the previously discovered lncRNAs that promote or inhibit tumor progression were derived from bulk RNA\u2010seq results. Data from single\u2010cell RNA sequencing (scRNA\u2010seq) and single\u2010cell assay for transposase\u2010accessible chromatin using sequencing (scATAC\u2010seq) in clear cell renal cell carcinoma (ccRCC) were integrated to precisely identify the lncRNAs that regulate tumor progression in ccRCC. The scRNA\u2010seq data of 23 ccRCC samples and the scATAC\u2010seq data of 19 samples were analysed, capturing the transcriptome of 121,106 cells and the epigenetic features of 61,693 cells, respectively. Results showed that lncRNA\n                    <jats:italic>RP11\u2010661C8.2<\/jats:italic>\n                    was associated with significant chromatin accessibility in ccRCC tumor cells by scATAC\u2010seq. Subsequently, integrated scRNA\u2010seq analysis and functional experiments in vitro and in vivo confirmed the role of\n                    <jats:italic>RP11\u2010661C8.2<\/jats:italic>\n                    in promoting the invasion, migration and epithelial\u2010mesenchymal transition (EMT) of ccRCC cells. In addition,\n                    <jats:italic>RP11\u2010661C8.2<\/jats:italic>\n                    played a role in up\u2010regulating\n                    <jats:italic>ITGAV<\/jats:italic>\n                    and activating the PI3K\/AKT signaling pathway, which may be the potential mechanism of promoting the EMT in ccRCC cells. This study identified the role of\n                    <jats:italic>RP11\u2010661C8.2<\/jats:italic>\n                    in ccRCC, which provided new reference basis and potential intervention targets for ccRCC.\n                  <\/jats:p>","DOI":"10.1002\/mc.70195","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:26:12Z","timestamp":1792520772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integration of scRNA\u2010Seq and scATAC\u2010Seq Revealed the Role of lncRNA\n                    <i>RP11\u2010661C8.2<\/i>\n                    by Promoting EMT in Clear Cell Renal Cell Carcinoma"],"prefix":"10.1002","author":[{"given":"Jizhen","family":"Cen","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"},{"name":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefang","family":"Liang","sequence":"additional","affiliation":[{"name":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine Guangxi Medical University Nanning China"},{"name":"School of Basic Medical Sciences Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wen","sequence":"additional","affiliation":[{"name":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengzhu","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaping","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio\u2010Cerebrovascular Diseases Control and Prevention, First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibiao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7440-1423","authenticated-orcid":false,"given":"Kaiqiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"},{"name":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3047-3138","authenticated-orcid":false,"given":"Zengnan","family":"Mo","sequence":"additional","affiliation":[{"name":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine Guangxi Medical University Nanning China"},{"name":"Department of Urology, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-5504","authenticated-orcid":false,"given":"Zhenyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine Guangxi Medical University Nanning China"},{"name":"School of Basic Medical Sciences Guangxi Medical University Nanning China"},{"name":"Department of Urology, The First Affiliated Hospital of Guangxi Medical University Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1097\/CM9.0000000000003442","article-title":"Comparative Analysis of Cancer Statistics in China and the United States in 2024","volume":"137","author":"Wu Y.","year":"2024","journal-title":"Chinese Medical 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