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In case that apoptosis process is blocked, necroptosis pathway is initiated with the activation of three key downstream mediators which are receptor\u2010interacting serine\/threonine protein kinase 1 (RIPK1), RIPK3, and mixed lineage kinase domain\u2010like protein (MLKL). The whole process eventually leads to destruction of the cell membrane integrity, swelling of organelles, and severe inflammation. Over the past decade, necroptosis has been found widely involved in life process of human beings and animals. In this review, we attempt to explore the therapeutic prospects of necroptosis regulators by describing its molecular mechanism and the role it played in pathological condition and tissue homeostasis, and to summarize the research and clinical applications of corresponding regulators including small molecule inhibitors, chemicals, Chinese herbal extracts, and biological agents in the treatment of various diseases.<\/jats:p>","DOI":"10.1002\/mco2.108","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T10:26:08Z","timestamp":1639995968000},"page":"730-755","source":"Crossref","is-referenced-by-count":93,"title":["The role of necroptosis in disease and treatment"],"prefix":"10.1002","volume":"2","author":[{"given":"Xiaoxiao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Affiliated Hospital of Xuzhou Medical University Xuzhou Medical University Xuzhou Jiangsu Province P. R. 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