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Cytokine storm leads to acute respiratory distress syndrome, pulmonary and other multiorgan failure, which is an important cause of COVID\u201019 progression and even death. Among them, activation of inflammatory pathways is a major factor in generating cytokine storms and causing dysregulated immune responses, which is closely related to the severity of viral infection. Therefore, elucidation of the inflammatory signaling pathway of SARS\u2010CoV\u20102 is important in providing otential therapeutic targets and treatment strategies against COVID\u201019. Here, we discuss the major inflammatory pathways in the pathogenesis of COVID\u201019, including induction, function, and downstream signaling, as well as existing and potential interventions targeting these cytokines or related signaling pathways. We believe that a comprehensive understanding of the regulatory pathways of COVID\u201019 immune dysregulation and inflammation will help develop better clinical therapy strategies to effectively control inflammatory diseases, such as COVID\u201019.<\/jats:p>","DOI":"10.1002\/mco2.154","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:16:42Z","timestamp":1659327402000},"source":"Crossref","is-referenced-by-count":60,"title":["Inflammatory pathways in COVID\u201019: Mechanism and therapeutic interventions"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9169-6231","authenticated-orcid":false,"given":"Yujie","family":"Jiang","sequence":"first","affiliation":[{"name":"Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu PR 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