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These \u201cmolecular scissors\u201d have offered us unprecedented abilities to manipulate nucleic acid sequences precisely in living cells from diverse species. Continued advances in genome editing exponentially broaden our knowledge of human genetics, epigenetics, molecular biology, and pathology. Currently, gene editing\u2010mediated therapies have led to impressive responses in patients with hematological diseases, including sickle cell disease and thalassemia. With the discovery of more efficient, precise and sophisticated gene\u2010editing tools, more therapeutic gene\u2010editing approaches will enter the clinic to treat various diseases, such as acquired immunodeficiency sydrome (AIDS), hematologic malignancies, and even severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. These initial successes have spurred the further innovation and development of gene\u2010editing technology. In this review, we will introduce the architecture and mechanism of the current gene\u2010editing tools, including clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR\u2010associated nuclease\u2010based tools and other protein\u2010based DNA targeting systems, and we summarize the meaningful applications of diverse technologies in preclinical studies, focusing on the establishment of disease models and diagnostic techniques. Finally, we provide a comprehensive overview of clinical information using gene\u2010editing therapeutics for treating various human diseases and emphasize the opportunities and challenges.<\/jats:p>","DOI":"10.1002\/mco2.155","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T01:44:07Z","timestamp":1657849447000},"source":"Crossref","is-referenced-by-count":16,"title":["Current landscape of gene\u2010editing technology in biomedicine: Applications, advantages, challenges, and perspectives"],"prefix":"10.1002","volume":"3","author":[{"given":"Weilin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Biotherapyy State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biotherapyy State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University  Chengdu People's Republic of China"},{"name":"Department of Hematology Hematology Research Laboratory State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University  Chengdu Sichuan P. 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