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NETs are web\u2010like structures composed of fibers, DNA, histones, and various neutrophil granule proteins. NETs can capture and kill pathogens, including bacteria, viruses, fungi, and protozoa. The process of NET formation is called NETosis. According to whether they depend on nicotinamide adenine dinucleotide phosphate (NADPH), NETosis can be divided into two categories: \u201csuicidal\u201d NETosis and \u201cvital\u201d NETosis. However, NET components, including neutrophil elastase, myeloperoxidase, and cell\u2010free DNA, cause a proinflammatory response and potentially severe diseases. Compelling evidence indicates a link between NETs and the pathogenesis of a number of diseases, including sepsis, systemic lupus erythematosus, rheumatoid arthritis, small\u2010vessel vasculitis, inflammatory bowel disease, cancer, COVID\u201019, and others. Therefore, targeting the process and products of NETosis is critical for treating diseases linked with NETosis. Researchers have discovered that several NET inhibitors, such as toll\u2010like receptor inhibitors and reactive oxygen species scavengers, can prevent uncontrolled NET development. This review summarizes the mechanism of NETosis, the receptors associated with NETosis, the pathology of NETosis\u2010induced diseases, and NETosis\u2010targeted therapy.<\/jats:p>","DOI":"10.1002\/mco2.162","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T12:29:57Z","timestamp":1660912197000},"source":"Crossref","is-referenced-by-count":217,"title":["Molecular mechanisms and therapeutic target of NETosis in diseases"],"prefix":"10.1002","volume":"3","author":[{"given":"Jiayu","family":"Huang","sequence":"first","affiliation":[{"name":"Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-2301","authenticated-orcid":false,"given":"Weiqi","family":"Hong","sequence":"additional","affiliation":[{"name":"Laboratory of 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