{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:44:23Z","timestamp":1791434663780,"version":"4.3.3"},"reference-count":313,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82061160372"],"award-info":[{"award-number":["82061160372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870506"],"award-info":[{"award-number":["81870506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vascular calcification (VC) is recognized as a pathological vascular disorder associated with various diseases, such as atherosclerosis, hypertension, aortic valve stenosis, coronary artery disease, diabetes mellitus, as well as chronic kidney disease. Therefore, it is a life\u2010threatening state for human health. There were several studies targeting mechanisms of VC that revealed the importance of vascular smooth muscle cells transdifferentiating, phosphorous and calcium milieu, as well as matrix vesicles on the progress of VC. However, the underlying molecular mechanisms of VC need to be elucidated. Though there is no acknowledged effective therapeutic strategy to reverse or cure VC clinically, recent evidence has proved that VC is not a passive irreversible comorbidity but an active process regulated by many factors. Some available approaches targeting the underlying molecular mechanism provide promising prospects for the therapy of VC. This review aims to summarize the novel findings on molecular mechanisms and therapeutic interventions of VC, including the role of inflammatory responses, endoplasmic reticulum stress, mitochondrial dysfunction, iron homeostasis, metabolic imbalance, and some related signaling pathways on VC progression. We also conclude some recent studies on controversial interventions in the clinical practice of VC, such as calcium channel blockers, renin\u2013angiotensin system inhibitions, statins, bisphosphonates, denosumab, vitamins, and ion conditioning agents.<\/jats:p>","DOI":"10.1002\/mco2.200","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T09:49:36Z","timestamp":1672739376000},"source":"Crossref","is-referenced-by-count":109,"title":["Vascular calcification: Molecular mechanisms and therapeutic interventions"],"prefix":"10.1002","volume":"4","author":[{"given":"Wei","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Cardiology, the Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen Guangdong China"},{"name":"Joint Laboratory of Guangdong\u2010Hong Kong\u2010Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic Disease Sun Yat\u2010sen University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8913-7131","authenticated-orcid":false,"given":"Wei","family":"Jie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen Guangdong China"},{"name":"Joint Laboratory of Guangdong\u2010Hong Kong\u2010Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic Disease Sun Yat\u2010sen University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen Guangdong China"},{"name":"Joint Laboratory of Guangdong\u2010Hong Kong\u2010Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic Disease Sun Yat\u2010sen University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11040213"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311576"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.08.026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-022-01860-9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2014.10.021"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091481"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328356c257"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.11.012"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1124-x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.07.019"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.05.016"},{"key":"e_1_2_11_14_1","volume-title":"Complex Coronary Artery Lesions","author":"Iftikhar SF","year":"2022"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.234914"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00419.2009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy010"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-014-0705-9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat945"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.10.6.2175444"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.759702"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082685"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2017.08.002"},{"issue":"2","key":"e_1_2_11_24_1","first-page":"190","article-title":"New research advances in relationship of endoplasmic reticulum stress and cardiovascular diseases","volume":"72","author":"Ji DR","year":"2020","journal-title":"Sheng Li Xue Bao"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00828-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq858"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810175"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102046"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00639-9"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"issue":"3","key":"e_1_2_11_31_1","first-page":"403","article-title":"Inflammation","volume":"65","author":"Audial S","year":"2015","journal-title":"Rev Prat"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2008.07.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.006"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.66537"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082013"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1876-4"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15268"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216415"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-1224"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800747"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.03.051"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.07.003"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.4110\/in.2016.16.1.26"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00661"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051593"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01058"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211001122"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308750"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28576"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-003-0071-z"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00339"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.03.010"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5193"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000605"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101887"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.05.004"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115392"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa299"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2522-3_15"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061899"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-67696-4_7"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00402"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.453"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.06.056"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.01.010"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02828-2020"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5343-0"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.12.024"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00852"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00027"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.08.114"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19232"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319745"},{"issue":"17","key":"e_1_2_11_74_1","first-page":"4497","article-title":"Inhibitory mechanism of icariin against oxidative stress\u2010induced calcification in aortic vascular smooth muscle cells","volume":"46","author":"Bai XJ","year":"2021","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0861-3"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000238"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070727"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7309"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/biosci\/biv084"},{"issue":"2","key":"e_1_2_11_80_1","first-page":"1","article-title":"Extracellular vesicle\u2010shuttling MicroRNAs regulate the development of inflammatory lung responses","volume":"1","author":"Carnino JM","year":"2018","journal-title":"Ann Pulm Crit Care Med"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315506"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.129"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442980"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.11.1055"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.07.085"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03083"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.4.1249-1259.2001"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00108-8"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13598"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.2009.02184.x"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-0814-6"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370213502619"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-016-1247-0"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.12.002"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.28873"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.992302"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5453.664"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.01.002"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.08.008"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt563"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00133-7"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004037200"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.482"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.160"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-021-10015-z"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02523"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1413-7"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0464-4"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S199459"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00350.2017"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017152117"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-13-13"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.539"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00070"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-013-1078-1"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0124-1"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.16"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2017.1417631"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-020-01592-7"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.826529"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.11.006"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-018-0263-x"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01294.x"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.611922"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.879752"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1159\/000163690"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph11040107"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(00)90244-8"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.08.014"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00116"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091173"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496492"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/896474"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/140728"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2019.108241"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1268047"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2018.12.005"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000511"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04923-5"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04735-7"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.692431"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904197"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228765"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.03.016"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.09.011"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-019-0216-0"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2016.1194143"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107179"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126428"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.029"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900077R"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.03.007"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.09.027"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108698"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00635-2"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2298-2"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002907"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179944"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0352-3"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15773"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217889"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-021-05039-w"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-022-01257-1"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130680"},{"issue":"5","key":"e_1_2_11_167_1","first-page":"1","article-title":"Role of the extracellular ATP\/pyrophosphate metabolism cycle in vascular calcification","volume":"5","author":"Villa\u2010Bellosta R","year":"2022","journal-title":"Purinergic Signal"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11030494"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2022.113051"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa222"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30605"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.693262"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0004422020"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-020-10081-w"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126270"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.887253"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2021.07.011"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI150051"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001082"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.583575"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-021-00623-0"},{"key":"e_1_2_11_182_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-021-02906-7"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.581230"},{"issue":"14","key":"e_1_2_11_184_1","first-page":"1","article-title":"Dickkopf1 (Dkk1) alleviates vascular calcification by regulating the degradation of phospholipase D1 (PLD1)","volume":"4","author":"Li X","year":"2022","journal-title":"J Cardiovasc Transl Res"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04164-8"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-04453-8"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.12997\/jla.2021.10.1.62"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.07.136"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03769-9"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.111883"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5729"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9490"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.02.016"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5298483"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.03.007"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503224"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102934"},{"key":"e_1_2_11_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.04.086"},{"key":"e_1_2_11_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.83"},{"key":"e_1_2_11_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2699"},{"key":"e_1_2_11_201_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100385R"},{"key":"e_1_2_11_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110074"},{"key":"e_1_2_11_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.11.017"},{"key":"e_1_2_11_204_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-020-10083-8"},{"key":"e_1_2_11_205_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170157"},{"key":"e_1_2_11_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14788-x"},{"key":"e_1_2_11_207_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9040427"},{"key":"e_1_2_11_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2020.06.005"},{"key":"e_1_2_11_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.01.033"},{"key":"e_1_2_11_210_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe3706"},{"key":"e_1_2_11_211_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504298"},{"key":"e_1_2_11_212_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-022-03195-4"},{"key":"e_1_2_11_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3275"},{"key":"e_1_2_11_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2020.106821"},{"key":"e_1_2_11_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100483"},{"key":"e_1_2_11_216_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-7355"},{"key":"e_1_2_11_217_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702221095456"},{"key":"e_1_2_11_218_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.722728"},{"key":"e_1_2_11_219_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4746"},{"key":"e_1_2_11_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.02.015"},{"key":"e_1_2_11_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.05.014"},{"key":"e_1_2_11_222_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010100"},{"key":"e_1_2_11_223_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02125836"},{"issue":"3","key":"e_1_2_11_224_1","first-page":"S157","article-title":"INSIGHT: international nifedipine GITS study intervention as a goal in hypertension treatment","volume":"10","author":"Brown MJ","year":"1996","journal-title":"J Hum Hypertens"},{"key":"e_1_2_11_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.01.060"},{"key":"e_1_2_11_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(01)00146-5"},{"key":"e_1_2_11_227_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.053708"},{"key":"e_1_2_11_228_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq725"},{"key":"e_1_2_11_229_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft459"},{"key":"e_1_2_11_230_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7115443"},{"key":"e_1_2_11_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2017.07.001"},{"key":"e_1_2_11_232_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-021-02589-8"},{"key":"e_1_2_11_233_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06562-9"},{"key":"e_1_2_11_234_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.16931020"},{"key":"e_1_2_11_235_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7382620"},{"key":"e_1_2_11_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.07.059"},{"key":"e_1_2_11_237_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.6.1410"},{"key":"e_1_2_11_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.04.013"},{"key":"e_1_2_11_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.481"},{"key":"e_1_2_11_240_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.53.331"},{"key":"e_1_2_11_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91121-P"},{"key":"e_1_2_11_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.017"},{"key":"e_1_2_11_243_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02198-6"},{"key":"e_1_2_11_244_1","article-title":"The role of angiotensin antagonism in coronary plaque regression: insights from the glagovian model","volume":"2021","author":"Alkatiri AH","year":"2021","journal-title":"Int J Vasc Med"},{"key":"e_1_2_11_245_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706114"},{"key":"e_1_2_11_246_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313832"},{"key":"e_1_2_11_247_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315737"},{"key":"e_1_2_11_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.04.015"},{"key":"e_1_2_11_249_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000127024.40516.ef"},{"key":"e_1_2_11_250_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08594-w"},{"key":"e_1_2_11_251_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9060168"},{"key":"e_1_2_11_252_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-018-0525-7"},{"key":"e_1_2_11_253_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMED.S10007"},{"key":"e_1_2_11_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.646"},{"key":"e_1_2_11_255_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.5.817"},{"key":"e_1_2_11_256_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.07.008"},{"key":"e_1_2_11_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2016.08.017"},{"key":"e_1_2_11_258_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-019-00987-0"},{"key":"e_1_2_11_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.12.091"},{"key":"e_1_2_11_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.050"},{"key":"e_1_2_11_261_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3676"},{"key":"e_1_2_11_262_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-020-05391-3"},{"key":"e_1_2_11_263_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080957"},{"key":"e_1_2_11_264_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.12.002"},{"key":"e_1_2_11_265_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2043"},{"key":"e_1_2_11_266_1","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2017.1336854"},{"key":"e_1_2_11_267_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00278.2020"},{"key":"e_1_2_11_268_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040896"},{"key":"e_1_2_11_269_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041222"},{"key":"e_1_2_11_270_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12624"},{"issue":"5","key":"e_1_2_11_271_1","first-page":"3676","article-title":"Vitamin K2 stimulates MC3T3\u2011E1 osteoblast differentiation and mineralization through autophagy induction","volume":"19","author":"Li W","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_11_272_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019060579"},{"key":"e_1_2_11_273_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.027011"},{"key":"e_1_2_11_274_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa079"},{"key":"e_1_2_11_275_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.4.999"},{"key":"e_1_2_11_276_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12858"},{"key":"e_1_2_11_277_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57111271"},{"key":"e_1_2_11_278_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.736538"},{"key":"e_1_2_11_279_1","article-title":"Vitamin D promotes MSC osteogenic differentiation stimulating cell adhesion and \u03b1V\u03b23 expression","volume":"2018","author":"Posa F","year":"2018","journal-title":"Stem Cells Int"},{"key":"e_1_2_11_280_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.05.020"},{"key":"e_1_2_11_281_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1220538"},{"key":"e_1_2_11_282_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-5666"},{"key":"e_1_2_11_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.09.068"},{"key":"e_1_2_11_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2019.118535"},{"issue":"4","key":"e_1_2_11_285_1","first-page":"311","article-title":"The role of magnesium in muscle contraction","volume":"16","author":"Limas CJ","year":"1971","journal-title":"Rev Eur Etud Clin Biol"},{"issue":"1","key":"e_1_2_11_286_1","first-page":"68","article-title":"Magnesium and vitamin D deficiency as a potential cause of immune dysfunction, cytokine storm and disseminated intravascular coagulation in COVID\u201019 patients","volume":"118","author":"DiNicolantonio JJ","year":"2021","journal-title":"Mo Med"},{"key":"e_1_2_11_287_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-021-00305-0"},{"key":"e_1_2_11_288_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2011.00538.x"},{"key":"e_1_2_11_289_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0228938"},{"key":"e_1_2_11_290_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12411"},{"key":"e_1_2_11_291_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20241-3"},{"key":"e_1_2_11_292_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.188"},{"key":"e_1_2_11_293_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.13921217"},{"key":"e_1_2_11_294_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017050492"},{"key":"e_1_2_11_295_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113083"},{"key":"e_1_2_11_296_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01584"},{"key":"e_1_2_11_297_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8090337"},{"key":"e_1_2_11_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2016.07.005"},{"key":"e_1_2_11_299_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-018-0471-9"},{"key":"e_1_2_11_300_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044195"},{"key":"e_1_2_11_301_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000726"},{"key":"e_1_2_11_302_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-019-00631-0"},{"key":"e_1_2_11_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.01.367"},{"key":"e_1_2_11_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.afnr.2015.11.001"},{"key":"e_1_2_11_305_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13752"},{"key":"e_1_2_11_306_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319720932455"},{"key":"e_1_2_11_307_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-04079-z"},{"key":"e_1_2_11_308_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-43229"},{"key":"e_1_2_11_309_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105466"},{"key":"e_1_2_11_310_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.104105"},{"key":"e_1_2_11_311_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/320849"},{"key":"e_1_2_11_312_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2006.tb00460.x"},{"key":"e_1_2_11_313_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2018.07.002"},{"key":"e_1_2_11_314_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198410043111411"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:41:36Z","timestamp":1692510096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,3]]},"references-count":313,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/mco2.200"],"URL":"https:\/\/doi.org\/10.1002\/mco2.200","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,3]]},"article-number":"e200"}}