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It is associated with systemic inflammation, myocardial infarction, neurological illness including ischemic strokes (e.g., cardiac and cerebral ischemia), and even death through multi\u2010organ failure. At the early stage, the virus infects the lung epithelial cells and is slowly transmitted to the other organs including the gastrointestinal tract, blood vessels, kidneys, heart, and brain. The neurological effect of the virus is mainly due to hypoxia\u2010driven reactive oxygen species (ROS) and generated cytokine storm. Internalization of SARS\u2010CoV\u20102 triggers ROS production and modulation of the immunological cascade which ultimately initiates the hypercoagulable state and vascular thrombosis. Suppression of immunological machinery and inhibition of ROS play an important role in neurological disturbances. So, COVID\u201019 associated damage to the central nervous system, patients need special care to prevent multi\u2010organ failure at later stages of disease progression. 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