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Current evidence suggests that the rapidly evolving coronavirus subvariants risk rendering vaccines and antibodies ineffective due to their potential to evade existing immunity, with enhanced transmission activity and higher reinfection rates that could lead to new outbreaks across the globe. The goal of viral management is to disrupt the viral life cycle as well as to relieve severe symptoms such as lung damage, cytokine storm, and organ failure. In the fight against viruses, the combination of viral genome sequencing, elucidation of the structure of viral proteins, and identifying proteins that are highly conserved across multiple coronaviruses has revealed many potential molecular targets. In addition, the time\u2010 and cost\u2010effective repurposing of preexisting antiviral drugs or approved\/clinical drugs for these targets offers considerable clinical advantages for COVID\u201019 patients. This review provides a comprehensive overview of various identified pathogenic targets and pathways as well as corresponding repurposed approved\/clinical drugs and their potential against COVID\u201019. 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