{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:33:44Z","timestamp":1792730024822,"version":"4.5.0"},"reference-count":289,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:00:00Z","timestamp":1685750400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["20200057"],"award-info":[{"award-number":["20200057"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gene therapy, a medical approach that involves the correction or replacement of defective and abnormal genes, plays an essential role in the treatment of complex and refractory diseases, such as hereditary diseases, cancer, and rheumatic immune diseases. Nucleic acids alone do not easily enter the target cells due to their easy degradation in vivo and the structure of the target cell membranes. The introduction of genes into biological cells is often dependent on gene delivery vectors, such as adenoviral vectors, which are commonly used in gene therapy. However, traditional viral vectors have strong immunogenicity while also presenting a potential infection risk. Recently, biomaterials have attracted attention for use as efficient gene delivery vehicles, because they can avoid the drawbacks associated with viral vectors. Biomaterials can improve the biological stability of nucleic acids and the efficiency of intracellular gene delivery. This review is focused on biomaterial\u2010based delivery systems in gene therapy and disease treatment. Herein, we review the recent developments and modalities of gene therapy. Additionally, we discuss nucleic acid delivery strategies, with a focus on biomaterial\u2010based gene delivery systems. Furthermore, the current applications of biomaterial\u2010based gene therapy are summarized.<\/jats:p>","DOI":"10.1002\/mco2.259","type":"journal-article","created":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T00:44:20Z","timestamp":1685839460000},"source":"Crossref","is-referenced-by-count":49,"title":["Biomaterial\u2010based gene therapy"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2380-6712","authenticated-orcid":false,"given":"Yi","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Stomatology The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-5891","authenticated-orcid":false,"given":"Yijun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"He","sequence":"additional","affiliation":[{"name":"Department of Stomatology Changsha Stomatological Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bairong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikun","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic (Burn) Surgery The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3666-8681","authenticated-orcid":false,"given":"Xiaoyan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Second Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjie","family":"Lei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1706910"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4025.949"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1990.1.3-331"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.2.98"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.10"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121876"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0437-z"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0508-6"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26301"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094534"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4672"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.6.2.187"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.02.010"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-012017-043332"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe2888"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-019-0156-z"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-615492"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.02.004"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.139683"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014467"},{"key":"e_1_2_13_22_1","doi-asserted-by":"crossref","unstructured":"The Lancet Oncology 2021 22 7 The Lancet O. CAR T\u2010cell therapy for solid tumours","DOI":"10.1016\/S1470-2045(21)00353-3"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00459-7"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1363139"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010162"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-016-5027-4"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1792"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-436568"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2019-CT036"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.34213"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2021.1843628"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.07.015"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.03.029"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119291"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00024"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-022-00292-4"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0017-4"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.06.008"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.2741\/s526"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0983-6"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01269-0"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00491-z"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607015103"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.09.004"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.06.029"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121020"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.05.020"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2016.009"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700175"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26714-w"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110618"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2022.2100342"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.01.011"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1480674"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/353043a0"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43056-2"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2008.07.005"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/0278364902021010833"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3006000"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2014.2342036"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006888107"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.735971"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1982.tb01257.x"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2031054"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.05.028"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2021.107891"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38661"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c05169"},{"issue":"6","key":"e_1_2_13_69_1","first-page":"551","article-title":"Delivery of interleukin\u201015 to B16 melanoma by electroporation leads to tumor regression and long\u2010term survival","volume":"13","author":"Marrero B","year":"2014","journal-title":"Technol Cancer Res Treat"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2021.107871"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.03.005"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00665-X"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-9092-4_17"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10189"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-53457-2_6"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.22.6.060504"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202007577"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300947"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950017734"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00791-7"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9LC00041K"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.08.002"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2003.082"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112861"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2019-0218"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.08.060"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301624"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases6020042"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01650-w"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505850"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0012-9"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2017.04.001"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.952755"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2004.05.004"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030565"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b16101"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0683-y"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200013338306"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.0459"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566523221666210423084233"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092179"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtadv.2022.100299"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020281"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp400036w"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01779"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB03124J"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9010022"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050583"},{"key":"e_1_2_13_109_1","first-page":"78","article-title":"Cell\u2010penetrating peptides transport therapeutics into cells","author":"Joshua D","year":"2015","journal-title":"Pharmacol Ther"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2012.03.002"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.18433\/J3G31Q"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b16378"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.07.001"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01397"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.013"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12770"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.61"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.07.027"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S250865"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0564-1"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.08.024"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn402657d"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200257"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar7002336"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1600102"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00963"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp3004176"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2020.1796628"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay3255"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.09.020"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.12.026"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.07.066"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7297"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030869"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.185"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2012.690282"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00203-9"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b01487"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00202-2"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(19990605)45:3<268::AID-JBM15>3.0.CO;2-Q"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2014.866651"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.09.012"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.01.022"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.12.001"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b00533"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201700114"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm800287z"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.01.009"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.089"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.06.007"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12172671"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2014.12.001"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-017-0114-y"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma11010122"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2019.03.007"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.04.002"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101686"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.05.034"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.115339"},{"key":"e_1_2_13_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.11.045"},{"key":"e_1_2_13_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.02.009"},{"key":"e_1_2_13_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17060381"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119315"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020487"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14112292"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1800095"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2017.06.019"},{"key":"e_1_2_13_168_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2032874"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-020-00724-5"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2019.2799"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.11.011"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b14517"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12917"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-018-2820-y"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b01462"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.7b02293"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2018.01.007"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101107"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR00481K"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.04.030"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp060132k"},{"key":"e_1_2_13_182_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101549"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134647"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.03.007"},{"key":"e_1_2_13_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.07.030"},{"key":"e_1_2_13_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111837"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062912"},{"key":"e_1_2_13_188_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016458104359"},{"key":"e_1_2_13_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.040"},{"key":"e_1_2_13_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00410-w"},{"issue":"2","key":"e_1_2_13_191_1","first-page":"113","article-title":"Exosomes in clinical trial and their production in compliance with good manufacturing practice","volume":"32","author":"Chen YS","year":"2020","journal-title":"Ci Ji Yi Xue Za Zhi"},{"key":"e_1_2_13_192_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR07622H"},{"key":"e_1_2_13_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.02.006"},{"key":"e_1_2_13_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.05.007"},{"key":"e_1_2_13_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22341"},{"key":"e_1_2_13_196_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c10458"},{"key":"e_1_2_13_197_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.747223"},{"key":"e_1_2_13_198_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abp9435"},{"key":"e_1_2_13_199_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00137"},{"key":"e_1_2_13_200_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2011.211"},{"issue":"1","key":"e_1_2_13_201_1","first-page":"11","article-title":"An overview on microspheres","volume":"3","author":"Gurung BD","year":"2020","journal-title":"International Journal of Health and Clinical Research"},{"key":"e_1_2_13_202_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40204-014-0033-8"},{"key":"e_1_2_13_203_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.933901"},{"key":"e_1_2_13_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2006.03.007"},{"key":"e_1_2_13_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1478"},{"key":"e_1_2_13_206_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910292"},{"key":"e_1_2_13_207_1","doi-asserted-by":"publisher","DOI":"10.3390\/scipharm87030020"},{"key":"e_1_2_13_208_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf3627"},{"key":"e_1_2_13_209_1","article-title":"Repair of infected bone defect with clindamycin\u2010tetrahedral DNA nanostructure complex\u2010loaded 3D bioprinted hybrid scaffold","volume":"435","author":"Li J","year":"2022","journal-title":"Chemical Engineering Journal"},{"key":"e_1_2_13_210_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201806538"},{"issue":"4","key":"e_1_2_13_211_1","article-title":"Recent developments and current applications of hydrogels in osteoarthritis","volume":"9","author":"Zhao T","year":"2022","journal-title":"Bioengineering (Basel)"},{"key":"e_1_2_13_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.004"},{"key":"e_1_2_13_213_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00673-4"},{"key":"e_1_2_13_214_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900172"},{"key":"e_1_2_13_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/0966-7822(96)00001-9"},{"key":"e_1_2_13_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.08.052"},{"key":"e_1_2_13_217_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c11040"},{"key":"e_1_2_13_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106564"},{"key":"e_1_2_13_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.08.003"},{"key":"e_1_2_13_220_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg3217"},{"key":"e_1_2_13_221_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.04992.x"},{"key":"e_1_2_13_222_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5239604"},{"key":"e_1_2_13_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.033"},{"key":"e_1_2_13_224_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01534"},{"key":"e_1_2_13_225_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12121219"},{"key":"e_1_2_13_226_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.582012"},{"issue":"3","key":"e_1_2_13_227_1","first-page":"1663","article-title":"COVID\u201019 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer\/BioNTech and moderna vaccines","volume":"25","author":"Meo SA","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_13_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.03.003"},{"key":"e_1_2_13_229_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004452"},{"key":"e_1_2_13_230_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_13_231_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2206573"},{"key":"e_1_2_13_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.11.022"},{"key":"e_1_2_13_233_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200268"},{"key":"e_1_2_13_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1635"},{"key":"e_1_2_13_235_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001812"},{"key":"e_1_2_13_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2011.04.006"},{"key":"e_1_2_13_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201402105"},{"key":"e_1_2_13_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_2_13_239_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029392"},{"key":"e_1_2_13_240_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc500320j"},{"key":"e_1_2_13_241_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520244113"},{"key":"e_1_2_13_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120580"},{"key":"e_1_2_13_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.05.031"},{"key":"e_1_2_13_244_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2015.027"},{"key":"e_1_2_13_245_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19463-2"},{"key":"e_1_2_13_246_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1027"},{"key":"e_1_2_13_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.05.040"},{"key":"e_1_2_13_248_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01589"},{"key":"e_1_2_13_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.046"},{"key":"e_1_2_13_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.01.014"},{"key":"e_1_2_13_251_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-010-9265-9"},{"key":"e_1_2_13_252_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB01610D"},{"key":"e_1_2_13_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.05.037"},{"key":"e_1_2_13_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.04.049"},{"key":"e_1_2_13_255_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b20071"},{"key":"e_1_2_13_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.71"},{"key":"e_1_2_13_257_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201302627"},{"key":"e_1_2_13_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2014.05.007"},{"key":"e_1_2_13_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.04.001"},{"key":"e_1_2_13_260_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4185"},{"key":"e_1_2_13_261_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn1128"},{"key":"e_1_2_13_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.03.007"},{"key":"e_1_2_13_263_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00422G"},{"key":"e_1_2_13_264_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9111570"},{"key":"e_1_2_13_265_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-017-0138-3"},{"key":"e_1_2_13_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.117435"},{"key":"e_1_2_13_267_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01474"},{"key":"e_1_2_13_268_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301970"},{"key":"e_1_2_13_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.06.002"},{"key":"e_1_2_13_270_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052318"},{"key":"e_1_2_13_271_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12060584"},{"key":"e_1_2_13_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121320"},{"key":"e_1_2_13_273_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.60"},{"key":"e_1_2_13_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.04.061"},{"key":"e_1_2_13_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121327"},{"key":"e_1_2_13_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113842"},{"key":"e_1_2_13_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.04.001"},{"key":"e_1_2_13_278_1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2017.01005"},{"key":"e_1_2_13_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_13_280_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.08.024"},{"key":"e_1_2_13_281_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.06.146"},{"key":"e_1_2_13_282_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S146942"},{"key":"e_1_2_13_283_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.245"},{"key":"e_1_2_13_284_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2333"},{"key":"e_1_2_13_285_1","article-title":"Functionalized DNA nanomaterials targeting toll\u2010like receptor 4 prevent bisphosphonate\u2010related osteonecrosis of the jaw via regulating mitochondrial homeostasis in macrophages","author":"Zhang T","year":"2023","journal-title":"Advanced Functional Materials"},{"key":"e_1_2_13_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.05.028"},{"key":"e_1_2_13_287_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1748758"},{"key":"e_1_2_13_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.05.009"},{"key":"e_1_2_13_289_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.08.099"},{"key":"e_1_2_13_290_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04996"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T20:38:44Z","timestamp":1692304724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":289,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/mco2.259"],"URL":"https:\/\/doi.org\/10.1002\/mco2.259","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"article-number":"e259"}}