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Organoid culture is an emerging 3D culture technology, and organoids derived from various organs and tissues, such as the brain, lung, heart, liver, and kidney, have been generated. Compared with traditional bidimensional culture, organoid culture systems have the unique advantage of conserving parental gene expression and mutation characteristics, as well as long\u2010term maintenance of the function and biological characteristics of the parental cells in vitro. All these features of organoids open up new opportunities for drug discovery, large\u2010scale drug screening, and precision medicine. Another major application of organoids is disease modeling, and especially various hereditary diseases that are difficult to model in vitro have been modeled with organoids by combining genome editing technologies. Herein, we introduce the development and current advances in the organoid technology field. We focus on the applications of organoids in basic biology and clinical research, and also highlight their limitations and future perspectives. We hope that this review can provide a valuable reference for the developments and applications of organoids.<\/jats:p>","DOI":"10.1002\/mco2.274","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T02:05:44Z","timestamp":1684375544000},"source":"Crossref","is-referenced-by-count":259,"title":["Organoids: The current status and biomedical applications"],"prefix":"10.1002","volume":"4","author":[{"given":"Siqi","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Biliary Tract Surgery Department of General Surgery West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijie","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Biliary Tract Surgery Department of General Surgery West China Hospital Sichuan University  Chengdu Sichuan Province 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