{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:31:01Z","timestamp":1793637061148,"version":"4.5.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108002"],"award-info":[{"award-number":["82020108002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82225005"],"award-info":[{"award-number":["82225005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200321"],"award-info":[{"award-number":["82200321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100509"],"award-info":[{"award-number":["32100509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20DZ2255400"],"award-info":[{"award-number":["20DZ2255400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21XD1421300"],"award-info":[{"award-number":["21XD1421300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["XZ2020ZR\u2010ZY35(Z)"],"award-info":[{"award-number":["XZ2020ZR\u2010ZY35(Z)"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["XZ202101ZR0003G"],"award-info":[{"award-number":["XZ202101ZR0003G"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["20ZR1443300"],"award-info":[{"award-number":["20ZR1443300"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BO 5271\/5\u20101"],"award-info":[{"award-number":["BO 5271\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Circulating circular RNAs (circRNAs) are emerging as novel biomarkers for cardiovascular diseases (CVDs). Machine learning can provide optimal predictions on the diagnosis of diseases. Here we performed a proof\u2010of\u2010concept study to determine if combining circRNAs with an artificial intelligence approach works in diagnosing CVD. We used acute myocardial infarction (AMI) as a model setup to prove the claim. We determined the expression level of five hypoxia\u2010induced circRNAs, including cZNF292, cAFF1, cDENND4C, cTHSD1, and cSRSF4, in the whole blood of coronary angiography positive AMI and negative non\u2010AMI patients. Based on feature selection by using lasso with 10\u2010fold cross validation, prediction model by logistic regression, and ROC curve analysis, we found that cZNF292 combined with clinical information (CM), including age, gender, body mass index, heart rate, and diastolic blood pressure, can predict AMI effectively. In a validation cohort, CM\u00a0+\u00a0cZNF292 can separate AMI and non\u2010AMI patients, unstable angina and AMI patients, acute coronary syndromes (ACS), and non\u2010ACS patients. RNA stability study demonstrated that cZNF292 was stable. Knockdown of cZNF292 in endothelial cells or cardiomyocytes showed anti\u2010apoptosis effects in oxygen glucose deprivation\/reoxygenation. Thus, we identify circulating cZNF292 as a potential biomarker for AMI and construct a prediction model \u201cCM\u00a0+\u00a0cZNF292.\u201d<\/jats:p>","DOI":"10.1002\/mco2.299","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T05:42:42Z","timestamp":1686721362000},"source":"Crossref","is-referenced-by-count":20,"title":["Diagnosis of acute myocardial infarction using a combination of circulating circular RNA cZNF292 and clinical information based on machine learning"],"prefix":"10.1002","volume":"4","author":[{"given":"Qiulian","family":"Zhou","sequence":"first","affiliation":[{"name":"Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science Shanghai University  Nantong China"},{"name":"Cardiac Regeneration and Ageing Lab Institute of Cardiovascular Sciences Shanghai Engineering Research Center of Organ Repair, School of Medicine Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u2010Niels","family":"Boeckel","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration University Frankfurt  Frankfurt Germany"},{"name":"Klinik und Poliklinik f\u00fcr Kardiologie Universit\u00e4tsklinikum Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai China"},{"name":"Department of Cardiology Shigatse People's Hospital  Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science Shanghai University  Nantong China"},{"name":"Cardiac Regeneration and Ageing Lab Institute of Cardiovascular Sciences Shanghai Engineering Research Center of Organ Repair, School of Medicine Shanghai University  Shanghai China"},{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzheng","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science Shanghai University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Lv","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science Shanghai University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science Shanghai University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Meng","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science Shanghai University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tongji Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pujiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tongji Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tongji Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tongji Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Tenth People's Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Dimmeler","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Regeneration University Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics (Shanghai University) Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science Shanghai University  Nantong China"},{"name":"Cardiac Regeneration and Ageing Lab Institute of Cardiovascular Sciences Shanghai Engineering Research Center of Organ Repair, School of Medicine Shanghai University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00889-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-020-0783-5"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"61","article-title":"Colchicine in cardiovascular disease: in\u2010depth review","volume":"145","author":"Deftereos SG","year":"2022","journal-title":"Circulation"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2493"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2018.35"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.09.022"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.560537"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2021.1891393"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.07.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0218-x"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"269","article-title":"Circles in the heart and cardiovascular system","volume":"116","author":"Lim TB","year":"2020","journal-title":"Cardiovasc Res"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.04.006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.196"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39918"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56617-2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22998"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027348"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.040"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2017.11.001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306319"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0377-8"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-023-00982-7"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.7653"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000147512.81966.ba"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2020.1725536"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.314937"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020187"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-021-02119-6"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902507R"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.04.011"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11523"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.320029"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.46123"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-011-0840-5"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.07.036"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx891"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:35:49Z","timestamp":1692318949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/mco2.299"],"URL":"https:\/\/doi.org\/10.1002\/mco2.299","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"article-number":"e299"}}