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It is distinct from macroautophagy and microautophagy. In recent years, the regulatory mechanisms of CMA have been gradually enriched, including the newly discovered NRF2 and p38\u2013TFEB signaling, as positive and negative regulatory pathways of CMA, respectively. Normal CMA activity is involved in the regulation of metabolism, aging, immunity, cell cycle, and other physiological processes, while CMA dysfunction may be involved in the occurrence of neurodegenerative disorders, tumors, intestinal disorders, atherosclerosis, and so on, which provides potential targets for the treatment and prediction of related diseases. This article describes the general process of CMA and its role in physiological activities and summarizes the connection between CMA and macroautophagy. In addition, human diseases that concern the dysfunction or protective role of CMA are discussed. Our review deepens the understanding of the mechanisms and physiological functions of CMA and provides a summary of past CMA research and a vision of future directions.<\/jats:p>","DOI":"10.1002\/mco2.347","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T04:05:38Z","timestamp":1693368338000},"source":"Crossref","is-referenced-by-count":110,"title":["Chaperone\u2010mediated autophagy: Molecular mechanisms, biological functions, and diseases"],"prefix":"10.1002","volume":"4","author":[{"given":"Ruchen","family":"Yao","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health, Inflammatory Bowel Disease Research Center Shanghai China"},{"name":"Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Shanghai Institute of Digestive Disease Shanghai 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