{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:13:02Z","timestamp":1790053982217,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Calcipotriol (CAL) has been widely studied as a fibrosis inhibitor and used to treat plaque psoriasis via transdermal administration. The clinical application of CAL to treat liver fibrosis is bottlenecked by its unsatisfactory pharmacokinetics, biodistribution, and side effects, such as hypercalcemia in patients. The exploration of CAL as a safe and effective antifibrotic agent remains a major challenge. Therefore, we rationally designed and synthesized a self\u2010assembled drug nanoparticle encapsulating CAL in its internal hydrophobic core for systematic injection (termed NPs\/CAL) and further investigated the beneficial effect of the nanomaterial on liver fibrosis. C57BL\/6 mice were used as the animal model, and human hepatic stellate cell line LX\u20102 was used as the cellular model of hepatic fibrogenesis. Immunofluorescence staining, flow cytometry, western blotting, immunohistochemical staining, and in vitro imaging were used for evaluating the efficacy of NPs\/CAL treatment. We found NPs\/CAL can be quickly internalized in vitro, thus potently deactivating LX\u20102 cells. In addition, NPs\/CAL improved blood circulation and the accumulation of CAL in liver tissue. Importantly, NPs\/CAL strongly contributed to the remission of liver fibrosis without inducing hypercalcemia. Overall, our work identifies a promising paradigm for the development of nanomaterial\u2010based agents for liver fibrosis therapy.<\/jats:p>","DOI":"10.1002\/mco2.354","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T10:19:44Z","timestamp":1693045184000},"source":"Crossref","is-referenced-by-count":7,"title":["Nano\u2010calcipotriol as a potent anti\u2010hepatic fibrosis agent"],"prefix":"10.1002","volume":"4","author":[{"given":"Yina","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of 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