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The regulation of long noncoding RNAs (lncRNAs) in HIF\u20101\u03b1\u2010driven tumor development remains unclear. LINC02774 is a nuclear lncRNA and that it is being reported for the first time in this study. We found the downregulation of LINC02774 in glioma and decreased with the degree of malignant, with its expression showing a negative correlation with the relative index of enhanced magnetic resonance (RIEMR). RIEMR\u2010associated LINC02774 was found to inhibit glycolysis by modulating the hypoxia pathway rather than the hypoxia response itself. LINC02774 interacted with its neighboring gene, RP58 (ZBTB18), to enhance the expression of PHD3, which catalyzed HIF\u20101\u03b1 hydroxylase and ubiquitination, leading to the downregulation of HIF\u20101\u03b1 expression. We also found that the function of LINC02774, dependent on PHD3, was diminished upon RP58 depletion. Notably, higher expression of RIEMR\u2010associated LINC02774 was associated with a favorable prognosis. 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