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Recent studies showed that SIK2 regulates the macrophage polarization to make a balance between inflammation and macrophage. Macrophage is critical to initiate immune regulation, however, whether SIK2 can be involved in immune regulation is not still well understood. Here, we revealed that the protein of SIK2 was highly expressed in thymus, spleen, lung, and brain. And SIK2 protein content increased in RAW264.7 and AHH1 cells with a time and dose\u2010dependent after\u2010ionizing radiation (IR). Inhibition of SIK2 could promote AHH1 cells apoptosis Moreover, we used the Cre\u2010LoxP system to construct the SIK2\n                    <jats:sup>+\/\u2212<\/jats:sup>\n                    mice, and the research on function suggested that the deficiency of SIK2 could promote the sensitivity of IR. The deficiency of SIK2 promoted the immune injury via inhibiting the maturation of T cells and B cells. Furthermore, the TCR\u03b2 rearrangement was inhibited by the deficiency of SIK2. Collectively, this study demonstrated that SIK2 provides an essential function of regulating immune injury, which will provide new ideas for the treatment of immune injury\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/mco2.366","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T01:53:24Z","timestamp":1694483604000},"source":"Crossref","is-referenced-by-count":7,"title":["Deficiency of salt\u2010inducible kinase 2 (SIK2) promotes immune injury by inhibiting the maturation of lymphocytes"],"prefix":"10.1002","volume":"4","author":[{"given":"Jiaojiao","family":"Zhu","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation Medicine  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science Shihezi University, Shihezi  Xinjiang Province P. R. 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