{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:49:14Z","timestamp":1792028954513,"version":"4.4.0"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0908000"],"award-info":[{"award-number":["2020YFA0908000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2303600"],"award-info":[{"award-number":["2022YFC2303600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20200109120205924"],"award-info":[{"award-number":["JCYJ20200109120205924"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["RCYX20221008092950121"],"award-info":[{"award-number":["RCYX20221008092950121"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sepsis is a difficult\u2010to\u2010treat systemic condition in which liver dysfunction acts as both regulator and target. However, the dynamic response of diverse intrahepatic cells to sepsis remains poorly characterized. Capsaicin (CAP), a multifunctional chemical derived from <jats:italic>chilli peppers<\/jats:italic>, has recently been shown to potentially possess anti\u2010inflammatory effects, which is also one of the main approaches for drug discovery against sepsis. We performed single\u2010cell RNA transcriptome sequencing on 86,830 intrahepatic cells isolated from normal mice, cecal ligation and puncture\u2010induced sepsis model mice and CAP\u2010treated mice. The transcriptional atlas of these cells revealed dynamic changes in hepatocytes, macrophages, neutrophils, and endothelial cells in response to sepsis. Among the extensive crosstalk across these major subtypes, KC_Cxcl10 shared strong potential interaction with other cells when responding to sepsis. CAP mitigated the severity of inflammation by partly reversing these pathophysiologic processes. Specific cell subpopulations in the liver act collectively to escalate inflammation, ultimately causing liver dysfunction. CAP displays its health\u2010promoting function by ameliorating liver dysfunction induced by sepsis. Our study provides valuable insights into the pathophysiology of sepsis and suggestions for future therapeutic gain.<\/jats:p>","DOI":"10.1002\/mco2.395","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:34:23Z","timestamp":1696613663000},"source":"Crossref","is-referenced-by-count":15,"title":["Single\u2010cell RNA sequencing reveals the effects of capsaicin in the treatment of sepsis\u2010induced liver injury"],"prefix":"10.1002","volume":"4","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"},{"name":"Institute of Basic Integrative Medicine \uff0cSchool of Traditional Chinese Medicine, and School of Pharmaceutical Sciences Southern Medical University  Guangzhou Guangdong China"},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs, Artemisinin Research Center, and Institute of Chinese Materia\u00a0Medica China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oncology Shenzhen People's Hospital The First Affiliated Hospital Southern University of Science and Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhuan","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Kwan","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Physiology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulin","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayun","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs, Artemisinin Research Center, and Institute of Chinese Materia\u00a0Medica China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs, Artemisinin Research Center, and Institute of Chinese Materia\u00a0Medica China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Shenzhen People's Hospital The First Affiliated Hospital Southern University of Science and Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"},{"name":"Institute of Basic Integrative Medicine \uff0cSchool of Traditional Chinese Medicine, and School of Pharmaceutical Sciences Southern Medical University  Guangzhou Guangdong China"},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs, Artemisinin Research Center, and Institute of Chinese Materia\u00a0Medica China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Emergency Shenzhen People's Hospital The First Affiliated Hospital Southern University of Science and Technology  Shenzhen City Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-0105","authenticated-orcid":false,"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Medicine, and Shenzhen Clinical Research Centre for Geriatrics Shenzhen People's Hospital First Affiliated Hospital of Southern University of Science and Technology Second Clinical Medicine College of Jinan University  Shenzhen Guangdong China"},{"name":"Institute of Basic Integrative Medicine \uff0cSchool of Traditional Chinese Medicine, and School of Pharmaceutical Sciences Southern Medical University  Guangzhou Guangdong China"},{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao\u2010di Herbs, Artemisinin Research Center, and Institute of Chinese Materia\u00a0Medica China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215376"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021333"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.012"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"629","article-title":"Focus: death: organ dysfunction in sepsis: an ominous trajectory from infection to death","volume":"92","author":"Caraballo C","year":"2019","journal-title":"Yale J Biol Med"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2014.889129"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.168"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.01069.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21480"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31149"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0134-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO00351D"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25235681"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2022.06.011"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"91","article-title":"Capsaicinoids in the hottest pepper Bhut Jolokia and its antioxidant and antiinflammatory activities","volume":"5","author":"Yunbao L","year":"2010","journal-title":"Nat Prod Commun"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000132975.02854.65"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.04.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.11.015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.06.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.08.022"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2022.06.011"},{"issue":"4","key":"e_1_2_10_23_1","first-page":"217","article-title":"Activation of the AP\u20101 transcription factor by inflammatory cytokines of the TNF family","volume":"7","author":"Kyriakis JM","year":"1999","journal-title":"Gene Expr"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07019"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021321"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202000928"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1607451"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.45"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250684"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00824-4"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0905496"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001257"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01068"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00464"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2062"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002104"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.033"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8095"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.06.022"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.05.003"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2MR0220-549R"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981851"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107001-00016"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00636-12"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020805"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.04.073"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.12.037"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14205"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02694"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.07.018"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44960"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.01.019"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01442-x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13112"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.193447"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871529X15666150108113236"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2011.02.003"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201910-1911TR"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000473"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2010.02705.x"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20577-3"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T07:31:07Z","timestamp":1699255867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/mco2.395"],"URL":"https:\/\/doi.org\/10.1002\/mco2.395","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"article-number":"e395"}}