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In this research, the S\u2010propargyl\u2010cysteine (SPRC), an endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S donor, was loaded on carbomer\u00a0hydrogel, and a copper sheet rat burn model was developed. Pathological changes in rat skin tissue were examined using hematoxylin\u2013eosin (HE) and Masson staining. The immunohistochemistry (IHC) staining was performed to detect the expression of Collagen I (Col I) and Collagen III (Col III). The mRNA levels of interleukin (IL)\u20106, Col I\u03b12, Col III\u03b11, tissue inhibitors of metalloproteinase (TIMP)\u20101, matrix metalloproteinase (MMP)\u20109, vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)\u2010\u03b21 were examined by quantitative real\u2010time chain polymerase reaction. The findings demonstrated that the collagen layer was thicker in the SPRC group during the proliferative phase, SPRC hydrogel promoted VEGF expression. In the late stage of wound healing, the expression of IL\u20106, TIMP\u20101, MMP\u20109, and TGF\u2010\u03b21 was inhibited, and the Col I content was closer to that of normal tissue. These results surface that SPRC hydrogel can promote wound healing and play a positive role in reducing scar formation. Our results imply that SPRC can facilitate wound healing and play a positive role in reducing scar formation.\n                  <\/jats:p>","DOI":"10.1002\/mco2.485","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T12:04:33Z","timestamp":1709381073000},"source":"Crossref","is-referenced-by-count":12,"title":["H\n                    <sub>2<\/sub>\n                    S donor S\u2010propargyl\u2010cysteine for skin wound healing improvement via smart transdermal delivery"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9462-2405","authenticated-orcid":false,"given":"Xiaoqing","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine Macau University of Science and Technology  Macau China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"State 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