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In addition to causing metabolic abnormalities such as insulin resistance (IR), elevated blood glucose and lipids, and ectopic fat deposition, obesity can also damage pancreatic islet cells, endothelial cells, and cardiomyocytes through chronic inflammation, and even promote the development of a microenvironment conducive to cancer initiation. Improper dietary habits and lack of physical exercise are important behavioral factors that increase the risk of obesity, which can affect gene expression through epigenetic modifications. Epigenetic alterations can occur in early stage of obesity, some of which are reversible, while others persist over time and lead to obesity\u2010related complications. Therefore, the dynamic adjustability of epigenetic modifications can be leveraged to reverse the development of obesity\u2010associated diseases through behavioral interventions, drugs, and bariatric surgery. This review provides a comprehensive summary of the impact of epigenetic regulation on the initiation and development of obesity\u2010associated cancers, type 2 diabetes, and cardiovascular diseases, establishing a theoretical basis for prevention, diagnosis, and treatment of these conditions.<\/jats:p>","DOI":"10.1002\/mco2.496","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T06:44:25Z","timestamp":1708757065000},"source":"Crossref","is-referenced-by-count":45,"title":["Epigenetic modifications in obesity\u2010associated diseases"],"prefix":"10.1002","volume":"5","author":[{"given":"Yiqian","family":"Long","sequence":"first","affiliation":[{"name":"Department of Pathology, Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, School of Basic Medicine Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Mao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, School of Basic Medicine Central South University Changsha Hunan China"},{"name":"NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, School of Basic Medicine Central South University Changsha Hunan China"},{"name":"Department of Oncology, Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2354-5321","authenticated-orcid":false,"given":"Yongguang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, School of Basic Medicine Central South University Changsha Hunan China"},{"name":"NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, Department of Thoracic Surgery Second Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, School of Basic Medicine Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"e_1_2_15_2_1","unstructured":"Obesity and overweight. 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