{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:58:33Z","timestamp":1778767113952,"version":"3.51.4"},"reference-count":74,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1I1A2060024"],"award-info":[{"award-number":["NRF\u20102021R1I1A2060024"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102022R1I1A1A01071593"],"award-info":[{"award-number":["NRF\u20102022R1I1A1A01071593"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer cachexia is a multifactorial condition that contributes to the death of about 20% of cancer patients. It has the potential to cause weight loss, reduction in muscle mass, and loss of fat tissue, significantly lowering the quality of life. Currently, there are no approved drugs for cancer cachexia. Here, we have explored the possible impact of brassinin (BSN) on cancer cachexia under in vitro and in vivo settings. After differentiation, C2C12 and 3T3\u2010L1 cells were incubated with colorectal carcinoma cells conditioned media or BSN. For preclinical studies, mice were injected with HT\u201029 cells followed by intraperitoneal administration of BSN, and muscle and adipose tissues were evaluated by Western blotting and hematoxylin and eosin staining. BSN effectively suppressed muscle atrophy by down\u2010regulating the levels of Muscle RING\u2010finger protein\u20101 and Atrogin\u20101, while also increasing the expression of myosin heavy chain in cachexia\u2010induced\u2010C2C12 myotubes. The induction of adipogenesis by BSN prevented adipocyte atrophy in cachexia\u2010induced 3T3\u2010L1 adipocytes. We also noted that BSN disrupted the interaction between COX\u20102 and signaling transducer and activator of transcription 3 (STAT3) promoter, leading to down\u2010regulation of STAT3 activation. Moreover, it was found that BSN inhibited weight loss in mice and demonstrated anti\u2010cachexic effects. Overall, our observations indicate that BSN can attenuate cancer cachexia through diverse mechanisms.<\/jats:p>","DOI":"10.1002\/mco2.558","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T07:30:46Z","timestamp":1716881446000},"source":"Crossref","is-referenced-by-count":6,"title":["Brassinin alleviates cancer cachexia by suppressing diverse inflammatory mechanisms in mice"],"prefix":"10.1002","volume":"5","author":[{"given":"Min Hee","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Science in Korean Medicine Kyung Hee University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Yun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine Kyung Hee University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Young","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine Kyung Hee University  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gautam","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and NUS Centre for Cancer Research (N2CR) Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-0612","authenticated-orcid":false,"given":"Kwang Seok","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Science in Korean Medicine Kyung Hee University  Seoul South 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