{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:56:40Z","timestamp":1778162200094,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974254"],"award-info":[{"award-number":["81974254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670431"],"award-info":[{"award-number":["81670431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771754"],"award-info":[{"award-number":["81771754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Novel Coronavirus disease 2019 (COVID\u201019) has spread rapidly around the world. Individuals with immune dysregulation and\/or on immunosuppressive therapy, such as rheumatic patients, are considered at greater risk for infections. However, the risks of patients with each subcategory of rheumatic diseases have not been reported. Here, we identified 100 rheumatic patients from 18,786 COVID\u201019 patients hospitalized in 23 centers affiliated to Hubei COVID\u201019 Rheumatology Alliance between January 1 and April 1, 2020. Demographic information, medical history, length of hospital stay, classification of disease severity, symptoms and signs, laboratory tests, disease outcome, computed tomography, and treatments information were collected. Compared to gout and ankylosing spondylitis (AS) patients, patients with connective tissue disease (CTD) tend to be more severe after COVID\u201019 infection (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.081). CTD patients also had lower lymphocyte counts, hemoglobin, and platelet counts (<jats:italic>p<\/jats:italic> values were 0.033,\u00a0&lt;\u00a00.001, and 0.071, respectively). Hydroxychloroquine therapy and low\u2010 to medium\u2010dose glucocorticoids before COVID\u201019 diagnosis reduced the progression of COVID\u201019 to severe\/critical conditions (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.001 for hydroxychloroquine; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.006 for glucocorticoids). Our data suggests that COVID\u201019 in CTD patients may be more severe compared to patients with AS or gout.<\/jats:p>","DOI":"10.1002\/mco2.56","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T18:15:38Z","timestamp":1612635338000},"page":"82-90","source":"Crossref","is-referenced-by-count":5,"title":["COVID\u201019 infection in patients with connective tissue disease: A multicity study in Hubei province, China"],"prefix":"10.1002","volume":"2","author":[{"given":"Cong","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaozhe","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Dong","sequence":"additional","affiliation":[{"name":"Jingzhou City Central Hospital of Hubei Province  Jingzhou Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Xiaogan Hospital Affiliated to Wuhan University of Science and Technology  Xiaogan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiang","family":"Hou","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Sciences China Three Gorges University  Yichang Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Zhongnan Hospital of Wuhan University  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anbing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Xiangyang Central Hospital  Xiangyang Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Wuhan Central Hospital  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongchu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Integrated Treatment General Hospital of Central Theater Command  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Wuhan Puren Hospital Affiliated to Wuhan University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilian","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianyou Hospital Affiliated to Wuhan University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aichun","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Prevention and Health Care Renmin Hospital of Wuhan University  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The Traditional Chinese Medical Hospital of Hubei Province  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Affliated Dongfeng Hospital Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The First People's Hospital of Jingzhou  Jingzhou Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangdong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huangshi Central Hospital of Edong Healthcare Group  Huangshi Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Hankou Hospital of Wuhan  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Xiaogan First People's Hospital  Xiaogan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology China Resources and Wisco General Hospital  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The First People's Hospital of Tianmen  Tianmen Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Enshi Tujia and Miao Autonomous Prefecture Central Hospital  Enshi Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linchong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Minda Hospital of Hubei Minzu University  Enshi Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huanggang Central HospitaI  Huanggang Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Wuhan No.1 Hospital  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30120-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30227-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217627"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0282-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105949"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30120-X"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25801"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1432"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1091"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.198"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.03.046"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0820-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2507"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"issue":"2","key":"e_1_2_10_16_1","first-page":"145","article-title":"The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID\u201019) in China","volume":"41","author":"Chinese Center for Disease Control and Prevention","year":"2020","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0819-2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102433"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39480"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210715"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0372-x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b01002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-2-69"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1849"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0156-0"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0371-y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30317-2"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.146"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3453"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.56","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.56","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.56","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:52:54Z","timestamp":1693583574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,4]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/mco2.56"],"URL":"https:\/\/doi.org\/10.1002\/mco2.56","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,4]]}}}