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PA28\u03b3 plays a significant role in a variety of immune\u2010related diseases. However, the exact role of PA28\u03b3 in the pathogenesis of OLP remains unclear. Here, we demonstrated that PA28\u03b3 is overexpressed in epithelial cells and inflammatory cells of OLP tissues but has no significant relationship with OLP subtypes. Functionally, keratinocytes with high PA28\u03b3 expression could induce dendritic cell (DC) maturation and promote the T\u2010cell differentiation into Th1 cells in response to the immune response. In addition, we found that a high level of PA28\u03b3 expression is associated with high numbers of infiltrating mature DCs and activated T\u2010cells in OLP tissues. Mechanistically, keratinocytes with high PA28\u03b3 expression could promote the secretion of C\u2013C motif chemokine (CCL)5, blocking CCL5 or\/and its receptor CD44 could inhibit the induction of T\u2010cell differentiation by keratinocytes with high PA28\u03b3 expression. In conclusion, we reveal that keratinocytes with high expression of PA28\u03b3 in OLP can induce DC maturation and promote T\u2010cell differentiation through the CCL5\u2010CD44 pathway, providing previously unidentified mechanistic insights into the mechanism of inflammatory progression in OLP.<\/jats:p>","DOI":"10.1002\/mco2.561","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T11:18:46Z","timestamp":1715167126000},"source":"Crossref","is-referenced-by-count":10,"title":["PA28\u03b3 induces dendritic cell maturation and activates T\u2010cell immune responses in oral lichen planus"],"prefix":"10.1002","volume":"5","author":[{"given":"Yimei","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 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