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The use of Mg\u2010based biomedical devices eliminates the need for biomaterial removal surgery after the healing process and reduces adverse effects induced by the implantation of permanent biomaterials. However, the high corrosion rate of Mg\u2010based implants leads to unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. To overcome these limitations, alloying Mg with suitable alloying elements and surface treatment come highly recommended. In this area, open questions remain on the behavior of Mg\u2010based biomaterials in the human body and the effects of different factors that have resulted in these challenges. In addition to that, many techniques are yet to be verified to turn these challenges into opportunities. Accordingly, this article aims to review major challenges and opportunities for Mg\u2010based biomaterials to minimize the challenges for the development of novel biomaterials made of Mg and its alloys.<\/jats:p>","DOI":"10.1002\/mco2.59","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T11:48:04Z","timestamp":1617882484000},"page":"123-144","source":"Crossref","is-referenced-by-count":254,"title":["Biodegradable magnesium\u2010based biomaterials: An overview of challenges and opportunities"],"prefix":"10.1002","volume":"2","author":[{"given":"Shukufe","family":"Amukarimi","sequence":"first","affiliation":[{"name":"Department of Tissue Engineering &amp; Regenerative Medicine, Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences (IUMS)  Tehran 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