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However, timely diagnosis and intervention are challenging due to sophisticated diagnostic methods. In this study, 673 healthy controls and 905 patients with cirrhosis were screened, and 660 healthy controls and 757 patients with cirrhosis, divided into the test (292 patients) and validation (465 patients) cohort, were analyzed after screening. A diagnostic model of the Stroop test (Stroop\u2010CN) was constructed by multivariate linear regression based on the results of healthy controls. The prevalence of MHE and the comparison results with psychometric hepatic encephalopathy score through the Stroop\u2010CN model were stable in the test and validation cohorts. Moreover, the prevalence of MHE remained significantly higher in patients with worse disease conditions marked as high Child\u2013Pugh grades and the Model for End\u2010stage Liver Disease and Sodium (MELD\u2010Na) scores in the test and validation cohort. The EuroQol 5\u2010D questionnaire revealed that patients with MHE had a worse QOL than those without MHE both in the test and validation cohort. In conclusion, an easy and practical Stroop\u2010CN model for MHE diagnosis based on the EncephalApp is established. It is found that a considerable number of Chinese patients with cirrhosis experience MHE, which significantly impacts their QOL.<\/jats:p>","DOI":"10.1002\/mco2.627","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T09:15:17Z","timestamp":1721034917000},"source":"Crossref","is-referenced-by-count":4,"title":["Detection of minimal hepatic encephalopathy in patients with cirrhosis based on the Stroop\u2010CN model (NCRCID\u2010CHESS 2106): a\u00a0prospective multicenter study"],"prefix":"10.1002","volume":"5","author":[{"given":"Xiaoyan","family":"Li","sequence":"first","affiliation":[{"name":"Medical School of Chinese PLA  Beijing China"},{"name":"Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases  Beijing 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