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To simulate lethal coronavirus disease 2019 (COVID\u201019) in senescent human patients, 80\u2010week\u2010old male hamsters are intranasally inoculated with different doses of SARS\u2010CoV\u20102 Omicron BA.5 variant. Exposure to a low dose of the Omicron BA.5 variant results in early activation of the innate immune response, followed by rapid viral clearance and minimal lung damage. However, a high dose of BA.5 results in impaired interferon signaling, cytokine storm, uncontrolled viral replication, and severe lung injury. To decrease viral load and reverse the deterioration of COVID\u201019, a new bio\u2010mimic decoy called CoVR\u2010MV is used as a preventive or therapeutic agent. Administration of CoVR\u2010MV as a preventive or therapeutic intervention in the early stages of infection can effectively suppress viral load, regulate the immune response, and rescue animals from death and critical illness. These findings underscore the risk associated with SARS\u2010CoV\u20102 Omicron BA.5 exposure in senescent hamsters and highlight the importance of early intervention to prevent disease progression.<\/jats:p>","DOI":"10.1002\/mco2.642","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:25:57Z","timestamp":1721377557000},"source":"Crossref","is-referenced-by-count":1,"title":["Decisive reversal of lethal coronavirus disease 2019 in senescent hamster by synchronic antiviral and immunoregulatory intervention"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4385-7085","authenticated-orcid":false,"given":"Xuan","family":"Liu","sequence":"first","affiliation":[{"name":"Clinical Center for Bio\u2010Therapy Zhongshan Hospital Fudan University (Xiamen Branch) Xiamen Fujian China"},{"name":"State Key Laboratory of Vaccines for Infectious Diseases, National Institute of Diagnostics and Vaccine Development in Infectious 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