{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:19:43Z","timestamp":1792815583132,"version":"4.5.0"},"reference-count":335,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802718"],"award-info":[{"award-number":["81802718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In the past, hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) was recognized as a toxic and dangerous gas; in recent years, with increased research, we have discovered that H\n                    <jats:sub>2<\/jats:sub>\n                    S can act as an endogenous regulatory transmitter. In mammals, H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010catalyzing enzymes, such as cystathionine\u2010\u03b2\u2010synthase, cystathionine\u2010\u03b3\u2010lyase, and 3\u2010mercaptopyruvate sulfurtransferase, are differentially expressed in a variety of tissues and affect a variety of biological functions, such as transcriptional and posttranslational modification of genes, activation of signaling pathways in the cell, and metabolic processes in tissues, by producing H\n                    <jats:sub>2<\/jats:sub>\n                    S. Various preclinical studies have shown that H\n                    <jats:sub>2<\/jats:sub>\n                    S affects physiological and pathological processes in the body. However, a detailed systematic summary of these roles in health and disease is lacking. Therefore, this review provides a thorough overview of the physiological roles of H\n                    <jats:sub>2<\/jats:sub>\n                    S in different systems and the diseases associated with disorders of H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolism, such as ischemia\u2013reperfusion injury, hypertension, neurodegenerative diseases, inflammatory bowel disease, and cancer. Meanwhile, this paper also introduces H\n                    <jats:sub>2<\/jats:sub>\n                    S donors and novel release modes, as well as the latest preclinical experimental results, aiming to provide researchers with new ideas to discover new diagnostic targets and therapeutic options.\n                  <\/jats:p>","DOI":"10.1002\/mco2.661","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T02:40:00Z","timestamp":1723862400000},"source":"Crossref","is-referenced-by-count":53,"title":["Role of hydrogen sulfide in health and disease"],"prefix":"10.1002","volume":"5","author":[{"given":"Yu\u2010Qing","family":"Jin","sequence":"first","affiliation":[{"name":"Henan International Joint Laboratory for Nuclear Protein Regulation School of Basic Medical Sciences, School of Stomatology Henan University  Kaifeng Henan 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